DNA sequence and comparative analysis of chimpanzee chromosome 22

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dc.contributor.authorH Watanabe-
dc.contributor.authorA Fujiyama-
dc.contributor.authorM Hattori-
dc.contributor.authorYong Seok Lee-
dc.contributor.authorJ E Cheong-
dc.contributor.authorSang-Haeng Choi-
dc.contributor.authorN Saitou-
dc.contributor.authorHong-Seog Park-
dc.contributor.authorS Y Wang-
dc.contributor.authorM L Yaspo-
dc.contributor.authorY Sakaki-
dc.date.accessioned2017-04-19T09:01:05Z-
dc.date.available2017-04-19T09:01:05Z-
dc.date.issued2004-
dc.identifier.issn0028-0836-
dc.identifier.uri10.1038/nature02564ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6495-
dc.description.abstractHuman-chimpanzee comparative genome research is essential for narrowing down genetic changes involved in the acquisition of unique human features, such as highly developed cognitive functions, bipedalism or the use of complex language. Here, we report the high-quality DNA sequence of 33.3 megabases of chimpanzee chromosome 22. By comparing the whole sequence with the human counterpart, chromosome 21, we found that 1.44% of the chromosome consists of single-base substitutions in addition to nearly 68,000 insertions or deletions. These differences are sufficient to generate changes in most of the proteins. Indeed, 83% of the 231 coding sequences, including functionally important genes, show differences at the amino acid sequence level. Furthermore, we demonstrate different expansion of particular subfamilies of retrotransposons between the lineages, suggesting different impacts of retrotranspositions on human and chimpanzee evolution. The genomic changes after speciation and their biological consequences seem more complex than originally hypothesized.-
dc.publisherSpringer-Nature Pub Group-
dc.titleDNA sequence and comparative analysis of chimpanzee chromosome 22-
dc.title.alternativeDNA sequence and comparative analysis of chimpanzee chromosome 22-
dc.typeArticle-
dc.citation.titleNature-
dc.citation.number6990-
dc.citation.endPage388-
dc.citation.startPage382-
dc.citation.volume429-
dc.contributor.affiliatedAuthorYong Seok Lee-
dc.contributor.affiliatedAuthorJ E Cheong-
dc.contributor.affiliatedAuthorSang-Haeng Choi-
dc.contributor.affiliatedAuthorHong-Seog Park-
dc.contributor.alternativeNameWatanabe-
dc.contributor.alternativeNameFujiyama-
dc.contributor.alternativeNameHattor-
dc.contributor.alternativeName이용석-
dc.contributor.alternativeName정지은-
dc.contributor.alternativeName최상행-
dc.contributor.alternativeNameSaitou-
dc.contributor.alternativeName박홍석-
dc.contributor.alternativeNameWang-
dc.contributor.alternativeNameYaspo-
dc.contributor.alternativeNameSakaki-
dc.identifier.bibliographicCitationNature, vol. 429, no. 6990, pp. 382-388-
dc.identifier.doi10.1038/nature02564-
dc.description.journalClassY-
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