Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis

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dc.contributor.authorWoo Song Lee-
dc.contributor.authorDae Woo Lee-
dc.contributor.authorYoung Il Baek-
dc.contributor.authorSo Jin An-
dc.contributor.authorKyung Hyun Cho-
dc.contributor.authorYang Kyu Choi-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorHo Yong Park-
dc.contributor.authorK H Bae-
dc.contributor.authorTae Sook Jeong-
dc.date.accessioned2017-04-19T09:01:05Z-
dc.date.available2017-04-19T09:01:05Z-
dc.date.issued2004-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2004.04.023ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6496-
dc.description.abstractThe sesquineolignan, saucerneol B (1), and dineolignans, manassantin A (2), and manassantin B (3), were isolated from the methanol extracts of Saururus chinensis root and elucidated by their spectroscopic data analysis. Compounds 1-3 inhibited hACAT-1 and hACAT-2 with IC50 values of 43.0 and 124.0μM for 1, of 39.0 and 8.0μM for 2, of 82.0μM and only 32% inhibition at 1mM for 3, respectively. The EtOAc-soluble fraction, which contained compounds 1-3, of methanol extracts of S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.-
dc.publisherElsevier-
dc.titleHuman ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis-
dc.title.alternativeHuman ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number12-
dc.citation.endPage3112-
dc.citation.startPage3109-
dc.citation.volume14-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.affiliatedAuthorDae Woo Lee-
dc.contributor.affiliatedAuthorYoung Il Baek-
dc.contributor.affiliatedAuthorSo Jin An-
dc.contributor.affiliatedAuthorKyung Hyun Cho-
dc.contributor.affiliatedAuthorYang Kyu Choi-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.affiliatedAuthorHo Yong Park-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName이대우-
dc.contributor.alternativeName백영일-
dc.contributor.alternativeName안소진-
dc.contributor.alternativeName조경현-
dc.contributor.alternativeName최양규-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName박호용-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName정태숙-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 14, no. 12, pp. 3109-3112-
dc.identifier.doi10.1016/j.bmcl.2004.04.023-
dc.subject.keywordhACAT-1 and hACAT-2-
dc.subject.keywordHypocholesterolemic activity-
dc.subject.keywordInhibitor-
dc.subject.keywordLignans-
dc.subject.keywordS. chinensis-
dc.subject.localhACAT-1 and hACAT-2-
dc.subject.localHypocholesterolemic activity-
dc.subject.localinhibitors-
dc.subject.localInhibitors-
dc.subject.localinhibitor-
dc.subject.localInhibitor-
dc.subject.locallignan-
dc.subject.localLignans-
dc.subject.localLignan-
dc.subject.locallignans-
dc.subject.localS. chinensis-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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