Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats

Cited 19 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorG S Choi-
dc.contributor.authorSangku Lee-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorM K Lee-
dc.contributor.authorJ S Lee-
dc.contributor.authorU J Jung-
dc.contributor.authorH J Kim-
dc.contributor.authorY B Park-
dc.contributor.authorSong Hae Bok-
dc.contributor.authorM S Choi-
dc.date.accessioned2017-04-19T09:01:06Z-
dc.date.available2017-04-19T09:01:06Z-
dc.date.issued2004-
dc.identifier.issn0968-0896-
dc.identifier.uri10.1016/j.bmc.2004.04.020ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6504-
dc.description.abstractThe lipid-lowering efficacy of hesperetin was revealed in preliminary studies on experimental animals. As such, the current study compared the effect of hesperetin 7-O-lauryl ether, with that of hesperetin and lovastatin on the lipid profile and cholesterol-regulating mechanism in high-cholesterol-fed rats. Male rats were fed a high-cholesterol diet (1%, wt/wt) or high-cholesterol diet supplemented with lovastatin (1, 0.02%, wt/wt), hesperetin (2, 0.02%, wt/wt), or hesperetin 7-O-lauryl ether (3, 0.031%, wt/wt) for six weeks. The supplemental amount of 3 was 0.066mmol/100g diet as an equivalent to the supplemental amount of 2. The plasma total cholesterol and triglyceride levels were significantly lowered by the 2 and 3 supplements compared with the control or 1-supplemented group. The hepatic HMG-CoA reductase activities were also significantly lower in all the supplemented groups compared with the control group, and the hepatic ACAT activity was significantly lower in the 2- and 3-supplemented groups. The supplementation of 3 resulted in a higher excretion of total neutral sterol and total fecal sterol compared with the control or 1-supplemented group. Accordingly, overall, compound 3, exhibited a more potent plasma lipid-lowering effect than compound 1 based on inhibiting cholesterol biosynthesis and esterification, while also increasing the fecal sterol excretion.-
dc.publisherElsevier-
dc.titleEvaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats-
dc.title.alternativeEvaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry-
dc.citation.number13-
dc.citation.endPage3605-
dc.citation.startPage3599-
dc.citation.volume12-
dc.contributor.affiliatedAuthorSangku Lee-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorSong Hae Bok-
dc.contributor.alternativeName최갑선-
dc.contributor.alternativeName이상구-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName이미경-
dc.contributor.alternativeName이정선-
dc.contributor.alternativeName정은주-
dc.contributor.alternativeName김혜진-
dc.contributor.alternativeName박용복-
dc.contributor.alternativeName복성해-
dc.contributor.alternativeName최명숙-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry, vol. 12, no. 13, pp. 3599-3605-
dc.identifier.doi10.1016/j.bmc.2004.04.020-
dc.subject.keywordACAT-
dc.subject.keywordHesperetin derivative-
dc.subject.keywordHMG-CoA reductase-
dc.subject.keywordLipid lowering-
dc.subject.localACAT (acyl-CoA: cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localcholesterol acytransferase (ACAT)-
dc.subject.localCholestrol Acyl Transferase (ACAT)-
dc.subject.localAcyl CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localACAT (Acyl-CoA:cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase-
dc.subject.localACAT-
dc.subject.localAcyl-CoA: cholesterol acyltransferase-
dc.subject.localacyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-coenzyme A: cholesterol acyltransferase (ACAT)-
dc.subject.localCholesterol acytransferase (ACAT)-
dc.subject.localcholestrol acyl transferase (ACAT)-
dc.subject.localHesperetin derivative-
dc.subject.localHMG-CoA reductase-
dc.subject.localLipid lowering-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.