Effect of flavon extracted from Artemisia absinthium on collagen induced arthritis in mice

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dc.contributor.authorK M Choi-
dc.contributor.authorD H Hwang-
dc.contributor.authorK M Shin-
dc.contributor.authorDo Young Yoon-
dc.contributor.authorD S Kim-
dc.date.accessioned2017-04-19T09:01:10Z-
dc.date.available2017-04-19T09:01:10Z-
dc.date.issued2004-
dc.identifier.issnI000-0172-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6521-
dc.description.abstractPurpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies and a stimulation index of the splenocytes of the mice were measured. IL-10 and TNF-α in the supernatants of the mice sera were measured by ELISA. mRNA expression for IL-10 and TNF-α in the splenocytes were tested. Results : Flavon extracted from Artemisia absinthium appears to be an effective suppressor of CIA in mice. The serum anti-collagen antibody level and stimulation index of the cultured splenocytes showed no significant differences among the three experimental groups. Also serum IL-10 and TNF-α levels did not show any significant differences among the three experimental groups. An increased expression of mRNA for IL-10 was observed in the splenocytes treated with flavon. Conclusion : With these results, flavon extracted from Artemisia absinthium appears to have a suppressive effect of CIA. The mechanism of the suppressive effect of flavon extracted from Artemisia absinthium may be from a stimulation of IL-10 production-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleEffect of flavon extracted from Artemisia absinthium on collagen induced arthritis in mice-
dc.title.alternativeEffect of flavon extracted from Artemisia absinthium on collagen induced arthritis in mice-
dc.typeArticle-
dc.citation.titleKorean Journal of Pedriatrics-
dc.citation.number6-
dc.citation.endPage684-
dc.citation.startPage677-
dc.citation.volume47-
dc.contributor.affiliatedAuthorDo Young Yoon-
dc.contributor.alternativeName최경민-
dc.contributor.alternativeName황대환-
dc.contributor.alternativeName신경미-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName김동수-
dc.identifier.bibliographicCitationKorean Journal of Pedriatrics, vol. 47, no. 6, pp. 677-684-
dc.subject.keywordflavon-
dc.subject.keywordartemisia absinthium-
dc.subject.keywordcollagen induced arthritis-
dc.subject.keywordIL-10-
dc.subject.keywordTNF-α-
dc.subject.localflavon-
dc.subject.localartemisia absinthium-
dc.subject.localcollagen induced arthritis-
dc.subject.localIL-10-
dc.subject.localTumor necrosis fa tor-α-
dc.subject.localTNFα-
dc.subject.localTumor necrosis factor (TNF)-α-
dc.subject.localTnf-α-
dc.subject.localTNF-a-
dc.subject.localTNF-alpha-
dc.subject.localTumor necrosis factor-α-
dc.subject.localtumor necrosis factor-alpha-
dc.subject.localTNFa-
dc.subject.localTumor necrosis factor alpha-
dc.subject.localTumor necrosis factor-alpha-
dc.subject.localTNF-α-
dc.subject.localtumor necrosis factor-α-
dc.description.journalClassN-
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