DC Field | Value | Language |
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dc.contributor.author | K M Choi | - |
dc.contributor.author | D H Hwang | - |
dc.contributor.author | K M Shin | - |
dc.contributor.author | Do Young Yoon | - |
dc.contributor.author | D S Kim | - |
dc.date.accessioned | 2017-04-19T09:01:10Z | - |
dc.date.available | 2017-04-19T09:01:10Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | I000-0172 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6521 | - |
dc.description.abstract | Purpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies and a stimulation index of the splenocytes of the mice were measured. IL-10 and TNF-α in the supernatants of the mice sera were measured by ELISA. mRNA expression for IL-10 and TNF-α in the splenocytes were tested. Results : Flavon extracted from Artemisia absinthium appears to be an effective suppressor of CIA in mice. The serum anti-collagen antibody level and stimulation index of the cultured splenocytes showed no significant differences among the three experimental groups. Also serum IL-10 and TNF-α levels did not show any significant differences among the three experimental groups. An increased expression of mRNA for IL-10 was observed in the splenocytes treated with flavon. Conclusion : With these results, flavon extracted from Artemisia absinthium appears to have a suppressive effect of CIA. The mechanism of the suppressive effect of flavon extracted from Artemisia absinthium may be from a stimulation of IL-10 production | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Effect of flavon extracted from Artemisia absinthium on collagen induced arthritis in mice | - |
dc.title.alternative | Effect of flavon extracted from Artemisia absinthium on collagen induced arthritis in mice | - |
dc.type | Article | - |
dc.citation.title | Korean Journal of Pedriatrics | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 684 | - |
dc.citation.startPage | 677 | - |
dc.citation.volume | 47 | - |
dc.contributor.affiliatedAuthor | Do Young Yoon | - |
dc.contributor.alternativeName | 최경민 | - |
dc.contributor.alternativeName | 황대환 | - |
dc.contributor.alternativeName | 신경미 | - |
dc.contributor.alternativeName | 윤도영 | - |
dc.contributor.alternativeName | 김동수 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pedriatrics, vol. 47, no. 6, pp. 677-684 | - |
dc.subject.keyword | flavon | - |
dc.subject.keyword | artemisia absinthium | - |
dc.subject.keyword | collagen induced arthritis | - |
dc.subject.keyword | IL-10 | - |
dc.subject.keyword | TNF-α | - |
dc.subject.local | flavon | - |
dc.subject.local | artemisia absinthium | - |
dc.subject.local | collagen induced arthritis | - |
dc.subject.local | IL-10 | - |
dc.subject.local | Tumor necrosis fa tor-α | - |
dc.subject.local | TNFα | - |
dc.subject.local | Tumor necrosis factor (TNF)-α | - |
dc.subject.local | Tnf-α | - |
dc.subject.local | TNF-a | - |
dc.subject.local | TNF-alpha | - |
dc.subject.local | Tumor necrosis factor-α | - |
dc.subject.local | tumor necrosis factor-alpha | - |
dc.subject.local | TNFa | - |
dc.subject.local | Tumor necrosis factor alpha | - |
dc.subject.local | Tumor necrosis factor-alpha | - |
dc.subject.local | TNF-α | - |
dc.subject.local | tumor necrosis factor-α | - |
dc.description.journalClass | N | - |
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