Human hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells

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dc.contributor.authorYoung Ik Lee-
dc.contributor.authorJung Me Hwang-
dc.contributor.authorJee Hye Im-
dc.contributor.authorYoon Ik Lee-
dc.contributor.authorNam-Soon Kim-
dc.contributor.authorD G Kim-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorH B Moon-
dc.contributor.authorS K Park-
dc.date.accessioned2017-04-19T09:01:10Z-
dc.date.available2017-04-19T09:01:10Z-
dc.date.issued2004-
dc.identifier.issn0021-9258-
dc.identifier.uri10.1074/jbc.M309280200ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6523-
dc.description.abstractThe hepatitis B virus-X protein (HBx) regulates fundamental aspects of mitochondrial physiology. We show that HBx down-regulates mitochondrial enzymes involved in electron transport in oxidative phosphorylation (complexes I, III, IV, and V) and sensitizes the mitochondrial membrane potential in a hepatoma cell line. HBx also increases the level of mitochondrial reactive oxygen species and lipid peroxide production. HBx does not activate apoptotic signaling, although it sensitizes hepatoma cells to apoptotic signaling, which is dependent on reactive oxygen species. Increased intrahepatic lipid peroxidation in HBx transgenic mice demonstrated that oxidative injury occurs as a direct result of HBx expression. Therefore, we conclude that mitochondrial dysfunction is a crucial pathophysiological factor in HBx-expressing hepatoma cells and provides an experimental rationale in the investigation of mitochondrial function in rapidly renewed tissues, as in hepatocellular carcinomas.-
dc.publisherAmer Soc Biochemistry Molecular Biology Inc-
dc.titleHuman hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells-
dc.title.alternativeHuman hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells-
dc.typeArticle-
dc.citation.titleJournal of Biological Chemistry-
dc.citation.number15-
dc.citation.endPage15471-
dc.citation.startPage15460-
dc.citation.volume279-
dc.contributor.affiliatedAuthorYoung Ik Lee-
dc.contributor.affiliatedAuthorJung Me Hwang-
dc.contributor.affiliatedAuthorJee Hye Im-
dc.contributor.affiliatedAuthorYoon Ik Lee-
dc.contributor.affiliatedAuthorNam-Soon Kim-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.affiliatedAuthorS K Park-
dc.contributor.alternativeName이영익-
dc.contributor.alternativeName황정미-
dc.contributor.alternativeName임지혜-
dc.contributor.alternativeName이윤익-
dc.contributor.alternativeName김남순-
dc.contributor.alternativeName김대건-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName문형배-
dc.contributor.alternativeName박숙경-
dc.identifier.bibliographicCitationJournal of Biological Chemistry, vol. 279, no. 15, pp. 15460-15471-
dc.identifier.doi10.1074/jbc.M309280200-
dc.description.journalClassY-
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Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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