DC Field | Value | Language |
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dc.contributor.author | W K Kim | - |
dc.contributor.author | D M Bolser | - |
dc.contributor.author | Jong Park | - |
dc.date.accessioned | 2017-04-19T09:01:11Z | - |
dc.date.available | 2017-04-19T09:01:11Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1367-4803 | - |
dc.identifier.uri | 10.1093/bioinformatics/bth053 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6525 | - |
dc.description.abstract | Motivation: Interacting pairs of proteins should co-evolve to maintain functional and structural complementarity. Consequently, such a pair of protein families shows similarity between their phylogenetic trees. Although the tendency of co-evolution has been known for various ligand-receptor pairs, it has not been studied systematically in the widest possible scope. We investigated the degree of co-evolution for more than 900 family pairs in a global protein structural interactome map (PSIMAP - a map of all the structural domain-domain interactions in the PDB). Results: There was significant correlation in 45% of the total SCOPs Family level pairs, rising to 78% in 454 reliable family interactions. Expectedly, the intra-molecular interactions between protein families showed stronger co-evolution than inter-molecular interactions. However, both types of interaction have a fundamentally similar pattern of co-evolution except for cases where different interfaces are involved. These results validate the use of co-evolution analysis with predictive methods such as PSIMAP to improve the accuracy of prediction based on 'homologous interaction'. The tendency of co-evolution enabled a nearly 5-fold enrichment in the identification of true interactions among the potential interlogues in PSIMAP. The estimated sensitivity was 79.2%, and the specificity was 78.6%. | - |
dc.publisher | Oxford Univ Press | - |
dc.title | Large-scale co-evolution analysis of protein structural interlogues using the global protein structural interactome map(PSIMAP) | - |
dc.title.alternative | Large-scale co-evolution analysis of protein structural interlogues using the global protein structural interactome map(PSIMAP) | - |
dc.type | Article | - |
dc.citation.title | Bioinformatics | - |
dc.citation.number | 7 | - |
dc.citation.endPage | 1150 | - |
dc.citation.startPage | 1138 | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Jong Park | - |
dc.contributor.alternativeName | 김완 | - |
dc.contributor.alternativeName | Bolser | - |
dc.contributor.alternativeName | 박종화 | - |
dc.identifier.bibliographicCitation | Bioinformatics, vol. 20, no. 7, pp. 1138-1150 | - |
dc.identifier.doi | 10.1093/bioinformatics/bth053 | - |
dc.description.journalClass | Y | - |
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