Solution conformation of α-conotoxin GIC, a novel potent antagonist of α3β2 nicotinic acetylcholine receptors

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dc.contributor.authorSeung-Wook Chi-
dc.contributor.authorDo-Hyoung Kim-
dc.contributor.authorB M Olivera-
dc.contributor.authorJ M McIntosh-
dc.contributor.authorKyou Hoon Han-
dc.date.accessioned2017-04-19T09:01:11Z-
dc.date.available2017-04-19T09:01:11Z-
dc.date.issued2004-
dc.identifier.issn0264-6021-
dc.identifier.uri10.1042/BJ20031792ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6526-
dc.description.abstractα-Conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. α-Conotoxin GIC potently blocks the α3β2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [McIntosh, Dowell, Watkins, Garrett, Yoshikami, and Olivera (2002) J. Biol. Chem. 277, 33610-33615]. We have now determined the three-dimensional solution structure of α-conotoxin GIC by NMR spectroscopy. The structure of α-conotoxin GIC is well defined with backbone and heavy atom root mean square deviations (residues 2-16) of 0.53 ? and 0.96 ? respectively. Structure and surface comparison of α-conotoxin GIC with the other α4/7 subfamily conotoxins reveals unique structural aspects of α-conotoxin GIC. In particular, the structural comparison between α-conotoxins GIC and MII indicates molecular features that may confer their similar receptor specificity profile, as well as those that provide the unique binding characteristics of α-conotoxin GIC.-
dc.publisherPortland Press Ltd-
dc.titleSolution conformation of α-conotoxin GIC, a novel potent antagonist of α3β2 nicotinic acetylcholine receptors-
dc.title.alternativeSolution conformation of α-conotoxin GIC, a novel potent antagonist of α3β2 nicotinic acetylcholine receptors-
dc.typeArticle-
dc.citation.titleBiochemical Journal-
dc.citation.number2-
dc.citation.endPage352-
dc.citation.startPage347-
dc.citation.volume380-
dc.contributor.affiliatedAuthorSeung-Wook Chi-
dc.contributor.affiliatedAuthorDo-Hyoung Kim-
dc.contributor.affiliatedAuthorKyou Hoon Han-
dc.contributor.alternativeName지승욱-
dc.contributor.alternativeName김도형-
dc.contributor.alternativeNameOlivera-
dc.contributor.alternativeNameMcIntosh-
dc.contributor.alternativeName한규훈-
dc.identifier.bibliographicCitationBiochemical Journal, vol. 380, no. 2, pp. 347-352-
dc.identifier.doi10.1042/BJ20031792-
dc.subject.keywordα-conotoxin-
dc.subject.keywordconus geographus (cone snail)-
dc.subject.keywordnicotinic acetylcholine receptor (nAChR)-
dc.subject.keywordNMR-
dc.subject.keywordsolution structure-
dc.subject.keywordvenom-
dc.subject.localα-conotoxin-
dc.subject.localα-Conotoxin-
dc.subject.localconus geographus (cone snail)-
dc.subject.localnicotinic acetylcholine receptor (nAChR)-
dc.subject.localNicotinic acetylcholine receptors (nAChRs)-
dc.subject.localNicotinic acetylcholine receptor-
dc.subject.localnicotinic acetylcholine receptor-
dc.subject.localNMR-
dc.subject.localnuclear magnetic resonance (Nmr)-
dc.subject.localNuclear magnetic resonance-
dc.subject.localnuclear magnetic resonance-
dc.subject.localNuclear magnetic resonance (NMR)-
dc.subject.localSolution structure-
dc.subject.localsolution structure-
dc.subject.localvenom-
dc.subject.localVenom-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > 1. Journal Articles
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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