Kaurane-type diterpene glycoside from the stem bark of Acanthopanax trifoliatus

Cited 20 time in scopus
Metadata Downloads
Title
Kaurane-type diterpene glycoside from the stem bark of Acanthopanax trifoliatus
Author(s)
P V Kiem; X F Cai; C V Minh; Jung Joon Lee; Y H Kim
Bibliographic Citation
Planta Medica, vol. 70, no. 3, pp. 282-284
Publication Year
2004
Abstract
A new diterpene glycoside, acantrifoside D (1), as well as three known diterpenes (2-4) were isolated from the stem bark of Acanthopanax trifoliatus from Vietnam. Based on 1D and 2D NMR spectroscopic data, their chemical structures were determined to be 16α,17-dihydroxy-ent-kauran-19-oic acid 16-O-β-D-glucopyranoside 19-O-β-D-glucopyranosyl ester (1), 16αH,17-isovalerate-ent-kauran-19-oic acid (2), ent-kaur-16-en-19-oic acid (3), and ent-pimara-8(14),15-dien-19-oic acid (4). Compounds 2-4 had strong inhibitory effects against COX-1 in an in vitro assay, with IC 50 values of 0.21, 0.15 and 0.19 mM, respectively.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2004-818926
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.