Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa

Cited 29 time in scopus
Metadata Downloads
Title
Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa
Author(s)
H Z Jin; Jeong-Hyung Lee; Dongho Lee; Hyun Sun LeeYoung-Soo Hong; Y H Kim; Jung Joon Lee
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 27, no. 6, pp. 926-928
Publication Year
2004
Abstract
Nine quinolone alkaloids (1 - 9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-κB-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC50 values between 0.91 μM and 15.91 μM. of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-κB activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.
Keyword
evodia rutaecarpanuclear factor activated T cellnuclear factor-κBquinolone alkaloid
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.27.926
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.