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- Title
- Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa
- Author(s)
- H Z Jin; Jeong-Hyung Lee; Dongho Lee; Hyun Sun Lee; Young-Soo Hong; Y H Kim; Jung Joon Lee
- Bibliographic Citation
- Biological & Pharmaceutical Bulletin, vol. 27, no. 6, pp. 926-928
- Publication Year
- 2004
- Abstract
- Nine quinolone alkaloids (1 - 9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-κB-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC50 values between 0.91 μM and 15.91 μM. of the N-methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N-methylated compounds showed comparable inhibitory effects against NF-κB activity. However, quinolone alkaloids without the N-methyl group showed a more selective inhibition of NFAT activity.
- Keyword
- evodia rutaecarpanuclear factor activated T cellnuclear factor-κBquinolone alkaloid
- ISSN
- 0918-6158
- Publisher
- Pharmaceutical Soc Japan
- DOI
- http://dx.doi.org/10.1248/bpb.27.926
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
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