Anti-inflammatory effect of kamebakaurin in in vivo animal models

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dc.contributor.authorJeong-Hyung Lee-
dc.contributor.authorJ K Choi-
dc.contributor.authorM S Noh-
dc.contributor.authorBang Yeon Hwang-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorJung Joon Lee-
dc.date.accessioned2017-04-19T09:01:14Z-
dc.date.available2017-04-19T09:01:14Z-
dc.date.issued2004-
dc.identifier.issn00320943-
dc.identifier.uri10.1055/s-2004-827152ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6547-
dc.description.abstractWe have identified kamebakaurin as an inhibitor of NF-κB and elucidated its molecular mechanism as a specific inhibitor in the DNA-binding activity of the p50 subunit of NF-κB. Here, we describe its anti-inflammatory activity in in vitro and in vivo models. Kamebakaurin dose-dependently inhibited not only the expression of inflammatory NF-κB target genes such as iNOS, COX-2, and TNF-α, but also the production of PGE2 and TNF-α in LPS-stimulated RAW264.7 cells. Moreover, in an air pouch model of inflammation, it suppressed the recruitment of neutrophils, production of TNF-α as well as PGE2 in the pouch exudates induced by carrageenan. In addition, kamebakaurin dose-dependently suppressed the inflammation in an adjuvant arthritis model. Oral administration of 20 mg/kg kamebakaurin resulted in the 75% decrease of paw volume. Taken together, kamebakaurin, a specific inhibitor of DNA-binding activity of the p50 subunit, is a valuable candidate for the intervention in NF-κB-dependent pathological conditions such as inflammation.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleAnti-inflammatory effect of kamebakaurin in in vivo animal models-
dc.title.alternativeAnti-inflammatory effect of kamebakaurin in in vivo animal models-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number6-
dc.citation.endPage530-
dc.citation.startPage526-
dc.citation.volume70-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.alternativeName이정형-
dc.contributor.alternativeName최진규-
dc.contributor.alternativeName노민수-
dc.contributor.alternativeName황방연-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName이정준-
dc.identifier.bibliographicCitationPlanta Medica, vol. 70, no. 6, pp. 526-530-
dc.identifier.doi10.1055/s-2004-827152-
dc.subject.keywordAdjuvant arthritis-
dc.subject.keywordAir pouch-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordDiterpene-
dc.subject.keywordKamebakaurin-
dc.subject.keywordNF-κB-
dc.subject.keywordp50-
dc.subject.localAdjuvant arthritis-
dc.subject.localAir pouch-
dc.subject.localAnti-inflammation-
dc.subject.localDiterpene-
dc.subject.localKamebakaurin-
dc.subject.localNF-κB-
dc.subject.localNF-kB-
dc.subject.localp50-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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