Inhibitory effects of multi-substituted benzylidenethiazolidine-2,4-diones on LDL oxidation

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dc.contributor.authorTae Sook Jeong-
dc.contributor.authorJu Ryoung Kim-
dc.contributor.authorKyung Soon Kim-
dc.contributor.authorKyung Hyun Cho-
dc.contributor.authorK H Bae-
dc.contributor.authorWoo Song Lee-
dc.date.accessioned2017-04-19T09:01:15Z-
dc.date.available2017-04-19T09:01:15Z-
dc.date.issued2004-
dc.identifier.issn09680896-
dc.identifier.uri10.1016/j.bmc.2004.06.001ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6551-
dc.description.abstractMulti-substituted benzylidenethiazolidine-2,4-diones 3a-h were synthesized by Knoevenagel condensation of di- or tri-substituted 4-hydroxybenzaldehydes [or 1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethanone] 1 with thiazolidine-2,4-dione (2) and evaluated for antioxidant activities of Cu2+-induced oxidation of human low-density lipoproteins (LDL). Among compounds 3a-h, 3a was superior to probucol in LDL-antioxidant activities and found to be ninefold more active than probucol. Due to its potency, compound 3a was tested for complementary in vitro investigations, such as TBARS assay (IC 50=0.1μM), lag time (240min at 1.5μM), relative electrophoretic mobility (REM) of ox-LDL (inhibition of 83% at 10μM), fragmentation of apoB-100 (inhibition of 61% at 5μM), and radical DPPH scavenging activity on copper-mediated LDL oxidation. In macrophage-mediated LDL oxidation, the TBARS formation was also inhibited by compound 3a.-
dc.publisherElsevier-
dc.titleInhibitory effects of multi-substituted benzylidenethiazolidine-2,4-diones on LDL oxidation-
dc.title.alternativeInhibitory effects of multi-substituted benzylidenethiazolidine-2,4-diones on LDL oxidation-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry-
dc.citation.number15-
dc.citation.endPage4023-
dc.citation.startPage4017-
dc.citation.volume12-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName김주령-
dc.contributor.alternativeName김경순-
dc.contributor.alternativeName조경현-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName이우송-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry, vol. 12, no. 15, pp. 4017-4023-
dc.identifier.doi10.1016/j.bmc.2004.06.001-
dc.subject.keywordantioxidant-
dc.subject.localantioxidant-
dc.subject.localAntioxidant-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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