DC Field | Value | Language |
---|---|---|
dc.contributor.author | K M Kim | - |
dc.contributor.author | Y Zhang | - |
dc.contributor.author | Bo Yeon Kim | - |
dc.contributor.author | S J Jeong | - |
dc.contributor.author | S A Lee | - |
dc.contributor.author | G D Kim | - |
dc.contributor.author | A Dritschilo | - |
dc.contributor.author | M Jung | - |
dc.date.accessioned | 2017-04-19T09:01:15Z | - |
dc.date.available | 2017-04-19T09:01:15Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1535-7163 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6552 | - |
dc.description.abstract | The transcription factor nuclear factor-κB (NF-κB) is activated in response to various stimuli including ionizing radiation. Disruption of NF-κB activation by mutant forms of the NF-κB inhibitor IκB-α or by proteasome inhibitors enhances both sensitivity to radiation and radiation-induced apoptosis. Human squamous carcinoma SCC-35 cells stably expressing a fragment (residues 1 to 84) of human p65 have been shown to exhibit down-regulation of both endogenous p65 mRNA and its protein. The mutant protein also inhibited radiation-induced NF-κB activation 6by preventing the proteolysis of IκB-α. This resulted in enhancement of cellular radiosensitivity and radiation-induced apoptosis. The NH2-terminal region of p65 is thus a potential molecular target for disruption of NF-κB activation and sensitization of tumors to radiotherapy. | - |
dc.publisher | Amer Assoc Cancer Research | - |
dc.title | The p65 subunit of nuclear factor-κB is a molecular target for radiation sensitization of human squamous carcinoma cells | - |
dc.title.alternative | The p65 subunit of nuclear factor-κB is a molecular target for radiation sensitization of human squamous carcinoma cells | - |
dc.type | Article | - |
dc.citation.title | Molecular Cancer Therapeutics | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 698 | - |
dc.citation.startPage | 693 | - |
dc.citation.volume | 3 | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.alternativeName | 김경 | - |
dc.contributor.alternativeName | Zhang | - |
dc.contributor.alternativeName | 김보연 | - |
dc.contributor.alternativeName | 정숙 | - |
dc.contributor.alternativeName | 이성 | - |
dc.contributor.alternativeName | 김건도 | - |
dc.contributor.alternativeName | Dritschilo | - |
dc.contributor.alternativeName | 정미라 | - |
dc.identifier.bibliographicCitation | Molecular Cancer Therapeutics, vol. 3, no. 6, pp. 693-698 | - |
dc.description.journalClass | Y | - |
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