DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jin Koo Kim | - |
dc.contributor.author | Kwang Dong Kim | - |
dc.contributor.author | E S Lee | - |
dc.contributor.author | Jong-Seok Lim | - |
dc.contributor.author | Hee Jun Cho | - |
dc.contributor.author | Hyun Kyung Yoon | - |
dc.contributor.author | Mi Young Cho | - |
dc.contributor.author | Kyoung Eun Baek | - |
dc.contributor.author | Yuk-Pheel Park | - |
dc.contributor.author | S G Paik | - |
dc.contributor.author | Yong Kyung Choe | - |
dc.contributor.author | Hee Gu Lee | - |
dc.date.accessioned | 2017-04-19T09:01:15Z | - |
dc.date.available | 2017-04-19T09:01:15Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | 10.1016/j.canlet.2004.02.021 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6553 | - |
dc.description.abstract | The potent anti-cancer agent cis-diamminedichloroplatinum (II) (cisplatin) is currently used for treating bladder cancer. However, clinical use of this drug for long periods is often limited because of the appearance of cisplatin-resistant bladder tumor cells. We employed the method of a differential display reverse transcriptase polymerase chain reaction to identify the differentially expressed genes in the parental human bladder cancer cell line, T24 and three cisplatin-resistant cell lines. We report here that cisplatin-resistant cell lines overexpress Bcl-2 family protein Bcl-2-related gene expressed in fetal liver (Bfl-1)/A1 as compared with their parental cell. Cisplatin and γ-irradiation induced expression of Bfl-1/A1 in T24R2 cells but not in T24 cells. Among Bcl-2 family members, Bfl-1/A1 showed the most significant alteration of the expression level in resistant cells. The nuclear translocation of nuclear factor-kappaB (NF-κB) by cisplatin and γ-irradiation selectively occurred in T24R2 cells. Mitochondrial depolarization and cell death by cisplatin were also prevented in T24R2 cells. Moreover, Bfl-1/A1 inhibited cisplatin- and TNF-α-induced apoptosis in BOSC23 cells. Our findings suggest that the induction of Bfl-1/A1 by NF-κB may be important in controlling resistance to cisplatin responses in bladder tumor cells. | - |
dc.publisher | Elsevier | - |
dc.title | Up-regulation of Bfl-1/A1 via NF-κB activation in cisplatin-resistant human bladder cancer cell line | - |
dc.title.alternative | Up-regulation of Bfl-1/A1 via NF-κB activation in cisplatin-resistant human bladder cancer cell line | - |
dc.type | Article | - |
dc.citation.title | Cancer Letters | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 70 | - |
dc.citation.startPage | 61 | - |
dc.citation.volume | 212 | - |
dc.contributor.affiliatedAuthor | Jin Koo Kim | - |
dc.contributor.affiliatedAuthor | Kwang Dong Kim | - |
dc.contributor.affiliatedAuthor | Jong-Seok Lim | - |
dc.contributor.affiliatedAuthor | Hee Jun Cho | - |
dc.contributor.affiliatedAuthor | Hyun Kyung Yoon | - |
dc.contributor.affiliatedAuthor | Mi Young Cho | - |
dc.contributor.affiliatedAuthor | Kyoung Eun Baek | - |
dc.contributor.affiliatedAuthor | Yuk-Pheel Park | - |
dc.contributor.affiliatedAuthor | Yong Kyung Choe | - |
dc.contributor.affiliatedAuthor | Hee Gu Lee | - |
dc.contributor.alternativeName | 김진구 | - |
dc.contributor.alternativeName | 김광동 | - |
dc.contributor.alternativeName | 이은식 | - |
dc.contributor.alternativeName | 임종석 | - |
dc.contributor.alternativeName | 조희준 | - |
dc.contributor.alternativeName | 윤현경 | - |
dc.contributor.alternativeName | 조미영 | - |
dc.contributor.alternativeName | 백경은 | - |
dc.contributor.alternativeName | 박육필 | - |
dc.contributor.alternativeName | 백상기 | - |
dc.contributor.alternativeName | 최용경 | - |
dc.contributor.alternativeName | 이희구 | - |
dc.identifier.bibliographicCitation | Cancer Letters, vol. 212, no. 1, pp. 61-70 | - |
dc.identifier.doi | 10.1016/j.canlet.2004.02.021 | - |
dc.subject.keyword | Bfl-1, Bcl-2-related gene expressed in fetal liver | - |
dc.subject.keyword | Bfl-1/A1 | - |
dc.subject.keyword | cisplatin, cis-diamminedichloroplatinum (II) | - |
dc.subject.keyword | cisplatin-resistant bladder cancer | - |
dc.subject.keyword | differential display | - |
dc.subject.keyword | NF-κB | - |
dc.subject.local | Bfl-1, Bcl-2-related gene expressed in fetal liver | - |
dc.subject.local | Bfl-1/A1 | - |
dc.subject.local | cisplatin, cis-diamminedichloroplatinum (II) | - |
dc.subject.local | cisplatin-resistant bladder cancer | - |
dc.subject.local | Differential display | - |
dc.subject.local | differential display | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.description.journalClass | Y | - |
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