Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus

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dc.contributor.authorEun Yi Moon-
dc.contributor.authorYing Hao Han-
dc.contributor.authorDong Seok Lee-
dc.contributor.authorYong Mahn Han-
dc.contributor.authorDae Yeul Yu-
dc.date.accessioned2017-04-19T09:01:18Z-
dc.date.available2017-04-19T09:01:18Z-
dc.date.issued2004-
dc.identifier.issn0014-2980-
dc.identifier.uri10.1002/eji.200424962ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6576-
dc.description.abstractIn the thymus, CD4+ or CD8+ single-positive (SP) thymocytes develop and mature by positive and negative selection or undergo 'death by neglect'. CD4+ or CD8+ SP then circulate to other lymphoid tissues. We have investigated the role of reactive oxygen species (ROS) in thymocyte development using peroxiredoxin II (PrxII)-null mice. The level of ROS in PrxII-null thymocytes is higher than that in wild-type mice. Deletion of the PrxII gene leads to enlargement of the thymus in young (9 weeks) and old (64 weeks) mice. The increased number of thymocytes in PrxII-null thymus is related to reduced hypodiploid cell formation. For mice on a normal diet, the ratio of SP to double-positive (DP) thymocytes in thymus of PrxII-null mice is lower than that in wild-type mice. After food restriction, which leads to increased ROS production, this ratio becomes much higher in PrxII-null thymus. The amount of apoptosis, induced by food restriction or by the injection of dexamethasone, is consistently lower in PrxII-null thymocytes than in wild-type thymocytes. In the presence of low serum concentrations, PrxII-deleted T cells proliferate more vigorously after stimulation with concanavalin A. Phytohemagglutinin- or OKT3-stimulated proliferation of human peripheral blood mononuclear cells is also higher in the presence of lower serum concentrations. Collectively, the results suggest for the first time that thymocyte maturations and proliferations are regulated by ROS levels induced by the deletion of PrxII gene in vivo.-
dc.publisherWiley-
dc.titleReactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus-
dc.title.alternativeReactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus-
dc.typeArticle-
dc.citation.titleEuropean Journal of Immunology-
dc.citation.number8-
dc.citation.endPage2128-
dc.citation.startPage2119-
dc.citation.volume34-
dc.contributor.affiliatedAuthorEun Yi Moon-
dc.contributor.affiliatedAuthorYing Hao Han-
dc.contributor.affiliatedAuthorDong Seok Lee-
dc.contributor.affiliatedAuthorYong Mahn Han-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.alternativeName문은이-
dc.contributor.alternativeName한영호-
dc.contributor.alternativeName이동석-
dc.contributor.alternativeName한용만-
dc.contributor.alternativeName유대열-
dc.identifier.bibliographicCitationEuropean Journal of Immunology, vol. 34, no. 8, pp. 2119-2128-
dc.identifier.doi10.1002/eji.200424962-
dc.subject.keywordnull mice-
dc.subject.keywordperoxiredoxin II-
dc.subject.keywordROS-
dc.subject.keywordthymocyte-
dc.subject.localnull mice-
dc.subject.localperoxiredoxin II-
dc.subject.localPeroxiredoxin 2-
dc.subject.localPeroxiredoxin-II-
dc.subject.localperoxiredoxin 2-
dc.subject.localperoxiredoxin II (Prx II)-
dc.subject.localPeroxiredoxin II-
dc.subject.localPeroxiredoxin2-
dc.subject.localReactive oxidative species-
dc.subject.localReactive oxygen species(ROS)-
dc.subject.localReactive oxygen species-
dc.subject.localReactive Oxygen Species (ROS)-
dc.subject.localReactive Oxygen Species-
dc.subject.localROS-
dc.subject.localReactive oxygen species (ROS)-
dc.subject.localreactive oxygen species-
dc.subject.localreactive oxygen species (ROS)-
dc.subject.localThymocytes-
dc.subject.localthymocyte-
dc.description.journalClassY-
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