Determination and significance of serum Interleukin-18 levels in patients with chronic hepatitis B virus infection = B형 간염 바이러스 만성 감염자에 있어서의 혈청 Interleukin-18의 측정 및 유용성

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dc.contributor.authorDo Young Yoon-
dc.contributor.authorKyung-Ae Lee-
dc.contributor.authorJ K Park-
dc.contributor.authorJ W Kim-
dc.date.accessioned2017-04-19T09:01:19Z-
dc.date.available2017-04-19T09:01:19Z-
dc.date.issued2004-
dc.identifier.issnI000-0170-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6578-
dc.description.abstractBackground : The aim of our study was to investigate the diagnostic value of interleukin-18 (IL-18) and other cytokines in chronic liver disease patients with hepatitis B virus (HBV), including chronic hepatitis B infection (CHB), liver cirhhosis (LC) with HBV, and hepatocellular carcinoma (HCC) with HBV. Methods : Serum levels of IL-18, interferon-gamma (INF-gamma), IL-4 and tumor necrosis factoralpha (TNF-alpha) were evaluated using ELISA in 87 patients with liver diseases with HBV (asymptomatic carriers, 9; CHB, 19; LC, 40; and HCC, 19), 13 patients with non-hepatic diseases (NHD), and 9 normal controls. Results : Serum IL-18 levels of CHB, LC with HBV and HCC with HBV patients were higher than those of healthy controls and asymptomatic carriers (P<0.05). Serum IFN-gamma and IL-4 levels were not significantly increased in all groups, but TNF-alpha levels were increased in LC and HCC patients (P<0.05). Conclusions : Determination of IL-18 may be useful in assessing the severity and predicting the prognosis of liver dieases with HBV.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleDetermination and significance of serum Interleukin-18 levels in patients with chronic hepatitis B virus infection = B형 간염 바이러스 만성 감염자에 있어서의 혈청 Interleukin-18의 측정 및 유용성-
dc.title.alternativeDetermination and significance of serum Interleukin-18 levels in patients with chronic hepatitis B virus infection-
dc.typeArticle-
dc.citation.titleKorean Journal of Laboratory Medicine-
dc.citation.number2-
dc.citation.endPage145-
dc.citation.startPage139-
dc.citation.volume24-
dc.contributor.affiliatedAuthorDo Young Yoon-
dc.contributor.affiliatedAuthorKyung-Ae Lee-
dc.contributor.alternativeName윤도영-
dc.contributor.alternativeName이경애-
dc.contributor.alternativeName박중경-
dc.contributor.alternativeName김종완-
dc.identifier.bibliographicCitationKorean Journal of Laboratory Medicine, vol. 24, no. 2, pp. 139-145-
dc.subject.keywordinterleukin-18-
dc.subject.keywordinterferon-gamma-
dc.subject.keywordinterleukin-4-
dc.subject.keywordtumor necrosis factor-alpha-
dc.subject.keywordcytokine-
dc.subject.keywordchronic liver diseases-
dc.subject.keywordhepatitis B virus-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordchronic hepatitis-
dc.subject.keywordliver cirrhosis-
dc.subject.localinterleukin-18-
dc.subject.localInterleukin-18-
dc.subject.localInterferon γ-
dc.subject.localinterferon-γ-
dc.subject.localInterferon-γ-
dc.subject.localinterferon-gamma-
dc.subject.localInterferon gamma-
dc.subject.localinterleukin-4-
dc.subject.localInterleukin-4-
dc.subject.localTumor necrosis fa tor-α-
dc.subject.localTNFα-
dc.subject.localTumor necrosis factor (TNF)-α-
dc.subject.localTnf-α-
dc.subject.localTNF-a-
dc.subject.localTNF-alpha-
dc.subject.localTumor necrosis factor-α-
dc.subject.localtumor necrosis factor-alpha-
dc.subject.localTNFa-
dc.subject.localTumor necrosis factor alpha-
dc.subject.localTumor necrosis factor-alpha-
dc.subject.localTNF-α-
dc.subject.localtumor necrosis factor-α-
dc.subject.localcytokine-
dc.subject.localCytokines-
dc.subject.localCytokine-
dc.subject.localchronic liver diseases-
dc.subject.localChronic liver disease-
dc.subject.localhepatitis B virus (HBV)-
dc.subject.localHepatitis B Virus-
dc.subject.localHepatitis B virus (HBV)-
dc.subject.localhepatitis B virus-
dc.subject.localhepatitis B Virus (HBV)-
dc.subject.localHepatitis B virus-
dc.subject.localHepatocellular carcinomas-
dc.subject.localHepatocellular carcinoma (HCC)-
dc.subject.localHepatocellular carcinoma-
dc.subject.localhepatocellular carcinoma (HCC)-
dc.subject.localhepatocellular carcinoma-
dc.subject.localchronic hepatitis-
dc.subject.localchronic Hepatitis-
dc.subject.localLiver cirrhosis-
dc.subject.localliver cirrhosis-
dc.description.journalClassY-
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