Immunohistochemical expression of galectin-3 in canine mammary tumours

Cited 7 time in scopus
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Title
Immunohistochemical expression of galectin-3 in canine mammary tumours
Author(s)
Yang Kyu Choi; S H Hong; B H Kim; Hyoung-Chin Kim; H J Woo; D Y Kim
Bibliographic Citation
Journal of Comparative Pathology, vol. 131, no. 2, pp. 242-245
Publication Year
2004
Abstract
Galectin-3, an endogenous β-galactoside-binding protein, plays a significant role in cell growth, cell activation, and cell to extracellular matrix interactions. To define the role of galectin-3 in canine mammary tumours, its expression was determined in mammary samples by immunohistochemical methods. In adjacent normal mammary glands, distant from the neoplasm, mammary epithelial cells showed little or no expression of galectin-3. In the majority of adenomas, the neoplastic cells showed moderate to strong galectin-3 immunoreactivity, but in the majority of adenocarcinomas such immunoreactivity was weak. These results suggest that the progression of canine mammary tumours is associated with low galectin-3 expression.
Keyword
DogGalectin-3Mammary neoplasiaTumour
ISSN
0021-9975
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jcpa.2004.02.002
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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