DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sang ku Lee | - |
dc.contributor.author | Jong Min Han | - |
dc.contributor.author | Hyun Jung Kim | - |
dc.contributor.author | Eung Soo Kim | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | Woo Song Lee | - |
dc.contributor.author | Kyung Hyun Cho | - |
dc.date.accessioned | 2017-04-19T09:01:20Z | - |
dc.date.available | 2017-04-19T09:01:20Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | 10.1016/j.bmcl.2004.06.101 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6590 | - |
dc.description.abstract | A series of cinnamic acid derivatives were prepared and their biological activities were evaluated in lipoprotein metabolism. Among the tested compounds, 4-hydroxycinnamic acid (l-phenylalanine methyl ester) amide (1) and 3,4-dihydroxyhydrocinammic acid (l-aspartic acid dibenzyl ester) amide (2) showed potent anti-atherogenic and anti-oxidant activities. A series of cinnamic acid derivatives were synthesized and their biological abilities on lipoprotein metabolism were examined. Among the tested compounds, 4-hydroxycinnamic acid (l-phenylalanine methyl ester) amide (1) and 3,4-dihydroxyhydrocinammic acid (l-aspartic acid dibenzyl ester) amide (2) inhibited human acyl-CoA:cholesterol acyltransferase-1 and -2 activities with apparent IC50 around 60 and 95 μM, respectively. Compounds 1 and 2 also served as an antioxidant against copper mediated low-density lipoproteins (LDL) oxidation with apparent IC 50 = 52 and 3 μM, compound 1 and 2, respectively. Additionally, decrease of HDL-particle size under presence of LDL was inhibited by the 1 at 307 μM of final concentration. Treatment of the 1 or 2 did not influence normal growth of RAW264.7 without detectable cytotoxic activity from a cell viability test. These results suggest that the new cinnamic acid derivatives possess useful biological activity as an anti-atherosclerotic agent with inhibition of cellular cholesterol storage and transport by the both ACAT, inhibition of LDL-oxidation, HDL particle size rearrangement. | - |
dc.publisher | Elsevier | - |
dc.title | Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size | - |
dc.title.alternative | Synthesis of cinnamic acid derivatives and their inhibitory effects on LDL-oxidation, acyl-CoA:cholesterol acyltransferase-1 and -2 activity, and decrease of HDL-particle size | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.number | 18 | - |
dc.citation.endPage | 4681 | - |
dc.citation.startPage | 4677 | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Sang ku Lee | - |
dc.contributor.affiliatedAuthor | Jong Min Han | - |
dc.contributor.affiliatedAuthor | Hyun Jung Kim | - |
dc.contributor.affiliatedAuthor | Eung Soo Kim | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.affiliatedAuthor | Kyung Hyun Cho | - |
dc.contributor.alternativeName | 이상구 | - |
dc.contributor.alternativeName | 한종민 | - |
dc.contributor.alternativeName | 김현정 | - |
dc.contributor.alternativeName | 김응수 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.contributor.alternativeName | 조경현 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 18, pp. 4677-4681 | - |
dc.identifier.doi | 10.1016/j.bmcl.2004.06.101 | - |
dc.description.journalClass | Y | - |
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