The distribution and expression of HERV families in the human genome

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Title
The distribution and expression of HERV families in the human genome
Author(s)
T H Kim; Yeo Jin Jeon; J M Yi; Dae Soo KimJae Won Huh; Cheol-Goo Hur; H S Kim
Bibliographic Citation
Molecules and Cells, vol. 18, no. 1, pp. 87-93
Publication Year
2004
Abstract
The families of human endogenous retroviruses (HERVs) are widely distributed in the human genome. Here we examined their distribution and expression. Approximately forty thousand HERV elements including truncated and solitary long terminal repeats (LTRs) were identified. These elements were most dense on chromosomes 4, 20, X, and Y. From an analysis of genomic stability during primate evolution, the 5′-LTR of the HERV genome (5′LTR - internal HERV - 3′LTR) appeared to be more often truncated than the 3′-LTR. ESTs derived from normal placenta, skeletal muscle, hypothalamus, and testis gave frequent matches to HERV elements. We present a classification of genes associated with HERV elements according to the hierarchical structure of gene ontology.
Keyword
distributionexpressionfunction categorygenome stabilityHERV elementshuman genomeidentification
ISSN
1016-8478
Publisher
South Korea
Type
Article
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
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