Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum

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Title
Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum
Author(s)
Seung Woong LeeMun Chual Rho; Jung Yeon Nam; Eun Hee Lim; Oh Eok Kwon; Y H Kim; Hyun Sun Lee; Young Kook Kim
Bibliographic Citation
Planta Medica, vol. 70, no. 7, pp. 678-679
Publication Year
2004
Abstract
Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl3 extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC50 value of 3.12 μM.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2004-827193
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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