Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum
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- Title
- Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum
- Author(s)
- Seung Woong Lee; Mun Chual Rho; Jung Yeon Nam; Eun Hee Lim; Oh Eok Kwon; Y H Kim; Hyun Sun Lee; Young Kook Kim
- Bibliographic Citation
- Planta Medica, vol. 70, no. 7, pp. 678-679
- Publication Year
- 2004
- Abstract
- Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl3 extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC50 value of 3.12 μM.
- ISSN
- 0032-0943
- Publisher
- Georg Thieme Verlag Kg
- Type
- Article
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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