Differential DNA methylation reprogramming of various repetitive sequences in mouse preimplantation embryos

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dc.contributor.authorSeok Ho Kim-
dc.contributor.authorYong-Kook Kang-
dc.contributor.authorDeog Bon Koo-
dc.contributor.authorM J Kang-
dc.contributor.authorS J Moon-
dc.contributor.authorKyung Kwang Lee-
dc.contributor.authorYong Mahn Han-
dc.date.accessioned2017-04-19T09:01:27Z-
dc.date.available2017-04-19T09:01:27Z-
dc.date.issued2004-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2004.09.023ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6628-
dc.description.abstractGenome-wide changes of DNA methylation by active and passive demethylation processes are typical features during preimplantation development. Here we provide an insight that epigenetic reprogramming of DNA methylation is regulated in a region-specific manner, not a genome-wide fashion. To address this hypothesis, methylation states of three repetitive genomic regions were monitored at various developmental stages in the mouse embryos. Active demethylation was not observed in the IAP sequences whereas methylation reprogramming of the satellite sequences was regulated only by the active mechanism. Etn elements were actively demethylated after fertilization, passively demethylated by the 8-cell stage, and de novo methylated at the morular and blastocyst stages, showing dynamic epigenetic changes. Thus, our findings suggest that the specific genomic regions or sequences may spatially/temporally have their unique characteristics in the reprogramming of the DNA methylation during preimplantation development.-
dc.publisherElsevier-
dc.titleDifferential DNA methylation reprogramming of various repetitive sequences in mouse preimplantation embryos-
dc.title.alternativeDifferential DNA methylation reprogramming of various repetitive sequences in mouse preimplantation embryos-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage63-
dc.citation.startPage58-
dc.citation.volume324-
dc.contributor.affiliatedAuthorSeok Ho Kim-
dc.contributor.affiliatedAuthorYong-Kook Kang-
dc.contributor.affiliatedAuthorDeog Bon Koo-
dc.contributor.affiliatedAuthorKyung Kwang Lee-
dc.contributor.affiliatedAuthorYong Mahn Han-
dc.contributor.alternativeName김석호-
dc.contributor.alternativeName강용국-
dc.contributor.alternativeName구덕본-
dc.contributor.alternativeName강만종-
dc.contributor.alternativeName문성주-
dc.contributor.alternativeName이경광-
dc.contributor.alternativeName한용만-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 324, no. 1, pp. 58-63-
dc.identifier.doi10.1016/j.bbrc.2004.09.023-
dc.subject.keywordDNA methylation-
dc.subject.keywordEpigenetic reprogramming-
dc.subject.keywordMouse-
dc.subject.keywordPreimplantation embryo-
dc.subject.keywordRepetitive sequences-
dc.subject.localDNA methylation-
dc.subject.localDNAmethylation-
dc.subject.localEpigenetic reprogramming-
dc.subject.localepigenetic reprogramming-
dc.subject.localmouse-
dc.subject.localMouse-
dc.subject.localMice-
dc.subject.localmice-
dc.subject.localpreimplantation embryo-
dc.subject.localPre-implantation embryos-
dc.subject.localPreimplantation embryo-
dc.subject.localRepetitive sequence-
dc.subject.localRepetitive sequences-
dc.description.journalClassY-
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Aging Convergence Research Center > 1. Journal Articles
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