Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compounds
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | N H Nam | - |
| dc.contributor.author | D H Hong | - |
| dc.contributor.author | Y J You | - |
| dc.contributor.author | Y Kim | - |
| dc.contributor.author | S C Bang | - |
| dc.contributor.author | Hwan Mook Kim | - |
| dc.contributor.author | B Z Ahn | - |
| dc.date.accessioned | 2017-04-19T09:01:28Z | - |
| dc.date.available | 2017-04-19T09:01:28Z | - |
| dc.date.issued | 2004 | - |
| dc.identifier.issn | 0253-6269 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6633 | - |
| dc.description.abstract | A series of 2, 5-dihydroxychalcones and related compounds were synthesized, and their cytotoxicities against tumor cell lines and human umbilical venous endothelial cells (HUVEC) evaluated. It was found that chalcones, with electron-withdrawing substituents on an A ring, exhibited significant cytotoxicities. Among the synthesized compounds, 2′-chloro-2, 5-dihydroxychalcone (9) was most potent, with an IC50 value as low as 0.31 μg/mL. This compound also exhibited a significant cytotoxic selectivity toward HUVEC. | - |
| dc.publisher | Pharmaceutical Soc Korea | - |
| dc.title | Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compounds | - |
| dc.title.alternative | Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compounds | - |
| dc.type | Article | - |
| dc.citation.title | Archives of Pharmacal Research | - |
| dc.citation.number | 6 | - |
| dc.citation.endPage | 588 | - |
| dc.citation.startPage | 581 | - |
| dc.citation.volume | 27 | - |
| dc.contributor.affiliatedAuthor | Hwan Mook Kim | - |
| dc.contributor.alternativeName | Nam | - |
| dc.contributor.alternativeName | 홍동호 | - |
| dc.contributor.alternativeName | 유영제 | - |
| dc.contributor.alternativeName | 김용 | - |
| dc.contributor.alternativeName | 방성철 | - |
| dc.contributor.alternativeName | 김환묵 | - |
| dc.contributor.alternativeName | 안병준 | - |
| dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 27, no. 6, pp. 581-588 | - |
| dc.identifier.doi | 10.1007/BF02980153 | - |
| dc.subject.keyword | chalcone | - |
| dc.subject.keyword | cytotoxicity | - |
| dc.subject.keyword | structure-activity relationship | - |
| dc.subject.local | Chalcone | - |
| dc.subject.local | Chalcones | - |
| dc.subject.local | chalcone | - |
| dc.subject.local | Cytotoxicity | - |
| dc.subject.local | cytotoxicity | - |
| dc.subject.local | Structure-activity relationship | - |
| dc.subject.local | Structure-activity relationships | - |
| dc.subject.local | structure-activity relationship | - |
| dc.subject.local | structure-activity relationships | - |
| dc.subject.local | structureactivity relationships | - |
| dc.description.journalClass | Y | - |
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