Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice

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dc.contributor.authorE J Park-
dc.contributor.authorJ X Nan-
dc.contributor.authorY Z Zhao-
dc.contributor.authorS H Lee-
dc.contributor.authorY H Kim-
dc.contributor.authorJeong Bum Nam-
dc.contributor.authorJung Joon Lee-
dc.contributor.authorD H Sohn-
dc.date.accessioned2017-04-19T09:01:28Z-
dc.date.available2017-04-19T09:01:28Z-
dc.date.issued2004-
dc.identifier.issn1742-7835-
dc.identifier.uri10.1111/j.1742-7843.2004.pto940607.xko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6634-
dc.description.abstractThe aim of this study was to investigate whether Eleutherococcus senticosus stems could attenuate D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. E. senticosus, known as Siberian ginseng, is a popular folk medicine used as a tonic in Asia. Preparations of E. senticosus used in this study were as follows; (i) 70% ethanol extract (ii) water extract (iii) ethanol-soluble part of the water extract (iv) polysaccharide obtained as an 80% ethanol insoluble of the water extract. Preparations were given by intraperitoneal (300 mg/kg and 50 mg/kg) or oral (300 mg/kg) injection at 12 hr and 1 hr before a D-galactosamine/lipopolysaccharide injection. The intraperitoneal injection of water extract and polysaccharide significantly lowered serum levels of tumour necrosis factor-α, aspartate transaminase and alanine transaminase, improved the histologic changes in liver, inhibited hepatocyte apoptosis confirmed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and DNA fragmentation assay, and suppressed the lethality induced by D-galactosamine/lipopolysaccharide. The oral administration of water extract and polysaccharide also reduced serum aspartate transaminase, alanine transaminase and tumour necrosis factor-α levels. In contrast 70% ethanol extract and ethanol-soluble part of the water extract had no protective effect when treated intraperitoneally or orally. These results indicate E. senticosus stems attenuate fulminant hepatic failure induced by D-galactosamine/lipopolysaccharide in mice and the protective effect is due to water-soluble polysaccharides in E. senticosus stems.-
dc.publisherWiley-
dc.titleWater-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice-
dc.title.alternativeWater-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice-
dc.typeArticle-
dc.citation.titleBasic & Clinical Pharmacology & Toxicology-
dc.citation.number6-
dc.citation.endPage304-
dc.citation.startPage298-
dc.citation.volume94-
dc.contributor.affiliatedAuthorJeong Bum Nam-
dc.contributor.affiliatedAuthorJung Joon Lee-
dc.contributor.alternativeName박은전-
dc.contributor.alternativeNameNan-
dc.contributor.alternativeNameZhao-
dc.contributor.alternativeName이성희-
dc.contributor.alternativeName김영호-
dc.contributor.alternativeName남정범-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName손동환-
dc.identifier.bibliographicCitationBasic & Clinical Pharmacology & Toxicology, vol. 94, no. 6, pp. 298-304-
dc.identifier.doi10.1111/j.1742-7843.2004.pto940607.x-
dc.description.journalClassY-
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