DC Field | Value | Language |
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dc.contributor.author | E J Park | - |
dc.contributor.author | J X Nan | - |
dc.contributor.author | Y Z Zhao | - |
dc.contributor.author | S H Lee | - |
dc.contributor.author | Y H Kim | - |
dc.contributor.author | Jeong Bum Nam | - |
dc.contributor.author | Jung Joon Lee | - |
dc.contributor.author | D H Sohn | - |
dc.date.accessioned | 2017-04-19T09:01:28Z | - |
dc.date.available | 2017-04-19T09:01:28Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1742-7835 | - |
dc.identifier.uri | 10.1111/j.1742-7843.2004.pto940607.x | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6634 | - |
dc.description.abstract | The aim of this study was to investigate whether Eleutherococcus senticosus stems could attenuate D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. E. senticosus, known as Siberian ginseng, is a popular folk medicine used as a tonic in Asia. Preparations of E. senticosus used in this study were as follows; (i) 70% ethanol extract (ii) water extract (iii) ethanol-soluble part of the water extract (iv) polysaccharide obtained as an 80% ethanol insoluble of the water extract. Preparations were given by intraperitoneal (300 mg/kg and 50 mg/kg) or oral (300 mg/kg) injection at 12 hr and 1 hr before a D-galactosamine/lipopolysaccharide injection. The intraperitoneal injection of water extract and polysaccharide significantly lowered serum levels of tumour necrosis factor-α, aspartate transaminase and alanine transaminase, improved the histologic changes in liver, inhibited hepatocyte apoptosis confirmed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling method and DNA fragmentation assay, and suppressed the lethality induced by D-galactosamine/lipopolysaccharide. The oral administration of water extract and polysaccharide also reduced serum aspartate transaminase, alanine transaminase and tumour necrosis factor-α levels. In contrast 70% ethanol extract and ethanol-soluble part of the water extract had no protective effect when treated intraperitoneally or orally. These results indicate E. senticosus stems attenuate fulminant hepatic failure induced by D-galactosamine/lipopolysaccharide in mice and the protective effect is due to water-soluble polysaccharides in E. senticosus stems. | - |
dc.publisher | Wiley | - |
dc.title | Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice | - |
dc.title.alternative | Water-soluble polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice | - |
dc.type | Article | - |
dc.citation.title | Basic & Clinical Pharmacology & Toxicology | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 304 | - |
dc.citation.startPage | 298 | - |
dc.citation.volume | 94 | - |
dc.contributor.affiliatedAuthor | Jeong Bum Nam | - |
dc.contributor.affiliatedAuthor | Jung Joon Lee | - |
dc.contributor.alternativeName | 박은전 | - |
dc.contributor.alternativeName | Nan | - |
dc.contributor.alternativeName | Zhao | - |
dc.contributor.alternativeName | 이성희 | - |
dc.contributor.alternativeName | 김영호 | - |
dc.contributor.alternativeName | 남정범 | - |
dc.contributor.alternativeName | 이정준 | - |
dc.contributor.alternativeName | 손동환 | - |
dc.identifier.bibliographicCitation | Basic & Clinical Pharmacology & Toxicology, vol. 94, no. 6, pp. 298-304 | - |
dc.identifier.doi | 10.1111/j.1742-7843.2004.pto940607.x | - |
dc.description.journalClass | Y | - |
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