Effect of Astilbe koreana on ultraviolet B (UVB)-induced inflammatory response in human keratinocytes

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dc.contributor.authorM K Na-
dc.contributor.authorByung Sun Min-
dc.contributor.authorRen Bo An-
dc.contributor.authorK S Song-
dc.contributor.authorY H Seong-
dc.contributor.authorK H Bae-
dc.date.accessioned2017-04-19T09:01:31Z-
dc.date.available2017-04-19T09:01:31Z-
dc.date.issued2004-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.27.1301ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6636-
dc.description.abstractThe EtOH extract from the rhizomes of Astilbe koreana (Saxifragaceae) exhibited potent antioxidant activity in our recent study. Since the oxidative stress is known to be involved in the inflammatory response after ultraviolet B (UVB) exposure, the ability of the A. koreana extract to inhibit UVB-induced prostaglandin E2 (PGE2) and nitric oxide (NO) production was examined. UVB irradiation (35 mJ/cm2) increased PGE2 and NO production, which were significantly decreased by pre-administration of the A. koreana extract in a dose-dependent manner. The A. koreana extract also preserved cellular antioxidant capacity after UVB irradiation, which was determined by glutathione (GSH) content. UVB irradiation enhanced the formation of ROS in the keratinocytes, which was determined using a 2,7′- dichlorofluorescein diacetate (DCFH-DA), a redox sensitive dye. The levels of intracellular reactive oxygen species (ROS) were also significantly reduced by pre-treatment of the A. koreana extract in a dose-dependent manner measured 9 h after UVB irradiation. The results suggest that the A. koreana extract may have a protective effect on the UVB-injured keratinocytes by inhibiting PGE 2 and NO production, possibly through the inhibition of intracellular ROS accumulation.-
dc.publisherPharmaceutical Soc Japan-
dc.titleEffect of Astilbe koreana on ultraviolet B (UVB)-induced inflammatory response in human keratinocytes-
dc.title.alternativeEffect of Astilbe koreana on ultraviolet B (UVB)-induced inflammatory response in human keratinocytes-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number8-
dc.citation.endPage1304-
dc.citation.startPage1301-
dc.citation.volume27-
dc.contributor.affiliatedAuthorByung Sun Min-
dc.contributor.affiliatedAuthorRen Bo An-
dc.contributor.alternativeName나민균-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeName안인파-
dc.contributor.alternativeName송경식-
dc.contributor.alternativeName성연희-
dc.contributor.alternativeName배기환-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 27, no. 8, pp. 1301-1304-
dc.identifier.doi10.1248/bpb.27.1301-
dc.subject.keywordAstilbe koreana-
dc.subject.keywordIntracellular reactive oxygen species (ROS)-
dc.subject.keywordSaxifragaceae-
dc.subject.keywordUltraviolet B (UVB)-induced prostaglandin E2 (PGE2) production-
dc.subject.keywordUVB-induced nitric oxide (NO) production-
dc.subject.localAstilbe koreana-
dc.subject.localastilbe koreana-
dc.subject.localIntracellular ROS-
dc.subject.localIntracellular reactive oxygen species (ROS)-
dc.subject.localSaxifragaceae-
dc.subject.localsaxifragaceae-
dc.subject.localUltraviolet B (UVB)-induced prostaglandin E2 (PGE2) production-
dc.subject.localUVB-induced NO production-
dc.subject.localUVB-induced nitric oxide (NO) production-
dc.description.journalClassY-
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