Inhibition of PTP1B by metabolites from Micromucor ramannianus var. amgulisporus CRM000232

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Title
Inhibition of PTP1B by metabolites from Micromucor ramannianus var. amgulisporus CRM000232
Author(s)
Hyuncheol Oh; Beom Seok Kim; Eun Young Bae; Min Soo KimBo Yeon Kim; H B Lee; Chang-Jin Kim; Jong Seog Ahn
Bibliographic Citation
Journal of Antibiotics, vol. 57, no. 8, pp. 528-531
Publication Year
2004
Abstract
In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.57.528
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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