Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells

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Title
Somatostatin controls LFA-1 gene expression by altering neuraminidase expression in spleen cells
Author(s)
Woon Kee Yoon; H J Kim; H Y Son; K S Jeong; S J Park; T H Kim; S H Kim; S R Kim; S Y Ryu
Bibliographic Citation
Anticancer Research, vol. 24, no. 4, pp. 2331-2336
Publication Year
2004
Abstract
This study investigated whether neuraminidase (Neu) affects LFA-1 mRNA expression in spleen cells and whether somatostatin (SOM) and substance P (SP) treatment induce changes in the Neu mRNA expression level in spleen cells. Neu treatments down-regulated the LFA-1 mRNA levels after culturing for 2 h. SOM increased the Neu mRNA level slightly after 24-h culture and strongly after 48-h culture. These results suggest that prolonged exposure to SOM may regulate the Neu activation pathway, which in turn impairs the regulation of LFA-1 expression.
Keyword
LFA-1neuraminidasesomatostatinsubstance P
ISSN
0250-7005
Publisher
Int Inst Anticancer Research
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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