Phenylpropanoids from Myristica fragrans houtt = 육두구(Myristica fragrans Houtt)로부터 phenylpropanoid의 분리

Cited 0 time in scopus
Metadata Downloads
Title
Phenylpropanoids from Myristica fragrans houtt = 육두구(Myristica fragrans Houtt)로부터 phenylpropanoid의 분리
Author(s)
M C Song; E M Ahn; M H Bang; S Y Kim; Y D Rho; Byoung-Mog Kwon; Hyun Sun Lee; N I Baek
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 47, no. 3, pp. 366-369
Publication Year
2004
Abstract
Myristica fragrans Houtt were extracted in 80% aq. MeOH and solvent fractionated using CHCl3, EtOAc, n-BuOH and water, successively. The n-BuOH fraction gave three phenylpropanoids through application of silica gel column chromatographies. The chemical structures of the phenylpropanoids were determined by the interpretation of several spectral data, including NMR and MS as meso-dihydroguaiaretic acid (1), nectandrin B (2) and syringin methyl ether (3). Compound 1, which was first isolated from this plant by authors, showed inhibitory activities with 60.0?2.1% (100 μg/ml), 42.6?0.9% (140 μg/ml) and 12.2?0.2% (200 μg/ml) on ACAT(acyl-CoA:Cholesterol Acyltransferase), chitin synthase III and HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase), respectively. Compound 3 showed inhibitory activities with 27.2?0.9% (100 μg/ml), 45.5?0.8% (200 μg/ml) on ACAT and chitin synthase III.
Keyword
myristica fragrans Houttmeso-dihydroguaiaretic acidnectandrin Bsyringin metyl etherchitin synthase Ⅲ
ISSN
I000-0171
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.