Inhibitors of the LPS-induced NF-κB activation from Artemisia sylvatica

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Title
Inhibitors of the LPS-induced NF-κB activation from Artemisia sylvatica
Author(s)
H Z Jin; Jeong-Hyung Lee; Dongho Lee; Young-Soo Hong; Y H Kim; Jung Joon Lee
Bibliographic Citation
Phytochemistry, vol. 65, no. 15, pp. 2247-2253
Publication Year
2004
Abstract
Three guaianolide type sesquiterpene lactones, 3α,4α- epoxyrupicolins C-E (1-3), together with six known sesquiterpenes (4-9) were isolated and identified from the methanol extract of the aerial parts of Artemisia sylvatica, and their biological activities were reported. Three guaianolide sesquiterpene lactones, 3α,4α-epoxyrupicolins C-E, together with six known sesquiterpenes, artemisolide, 3-methoxytanapartholide, deacetyllaurenobiolide, moxartenolide as well as arteminolides B and D were isolated by bioassay-guided fractionation from the methanol extract of the aerial parts of Artemisia sylvatica using the NF-κB mediated reporter gene assay. All isolated compounds displayed inhibitory activity on the LPS-induced NF-κB activation, NO production, and TNF-α production with IC 50 values of 0.49-7.17, 1.46-6.16, and 3.19-27.76 μM, respectively, in RAW264.7 cells. It was also established that arteminolide B suppressed the expression of NF-κB target genes such as iNOS and COX-2. This is the first report of NF-κB inhibitory activities of these compounds and supports the pharmacological use of Artemisia sylvatica, which has been employed as an herbal medicine for the treatment of inflammation.
Keyword
artemisia sylvaticacompositaeCOX-2iNOSNF-κBNOsesquiterpene lactoneTNF-α
ISSN
0031-9422
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.phytochem.2004.06.034
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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