Single and Four-week oral toxicity studies of difructose dianhydrides(DFA IV) in sprague-dawley rats = Difructose dianhydrides(DFA IV)의 랫드를 이용한 단회 및 4주간 반복 경구투여 독성시험

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Title
Single and Four-week oral toxicity studies of difructose dianhydrides(DFA IV) in sprague-dawley rats = Difructose dianhydrides(DFA IV)의 랫드를 이용한 단회 및 4주간 반복 경구투여 독성시험
Author(s)
Chang Woo Lee; Myong Lyoll Lee; Hwan Mook Kim; Woon Kee Yoon; S H Kim; H Y Son; Hyoung-Chin kim
Bibliographic Citation
Journal of Toxicology and Pubic Health, vol. 20, no. 3, pp. 263-272
Publication Year
2004
Abstract
This study was to investigate single and repeated-dose toxicities of DFA IV, a new candidate of nutraceutical which has preventive effect on anemia and osteoporosis. In single-dose oral toxicity study, the test article were administered once by gavage to rats at dose level of 0, 2,000 and 5,000 mg/kg. No dead animal, abnormal sign and abnormal necropsy finding was found in control and treated groups. Thus the approximate lethal dose of DFA IV was considered to be higher than 5,000 mg/kg in rats. In four week repeated dose oral toxicity study, the test article was administered once daily by gavage to rats at dose levels of 0, 500, 1,000 and 2,000 mg/kg. No abnormality was observed in mortality, clinical findings, body weight changes, food and water consumptions, opthalmoscopic findings, hematological findings, necropsy findings, organ weights and histopathological findings. In urinalysis, specific gravity was increased in 2,000 mg/kg groups of male rats. In serum biochemical analysis, creatine phosphokinase was increased in all treatment groups of male rats. These increases in urine specific gravity and serum creatine phosphokinase activity were not accompanied with related signs such as histopathological changes or clinical findings. In conclusion, four week repeated oral dose of DFA IV to rats did not cause apparent toxicological change at the dose of 500, 1,000 or 2000 mg/kg body weight. Thus it is suggested that no-observed-adverse-effect level (NOAEL) of DFA IV in rats would be 2,000 mg/kg/day body weight.
Keyword
4-week repeated dose toxicitynutraceuticalsanemiaosteoporosispreclinical toxicitydifructose dianhydride (DFA Ⅳ)
ISSN
I000-0084
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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