Enhancement of tyrosinase inhibition of the extract of Veratrum patulum using cellulase

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dc.contributor.authorDong Hyun Kim-
dc.contributor.authorJin Hee Kim-
dc.contributor.authorSeung Hwa Baek-
dc.contributor.authorJ H Seo-
dc.contributor.authorYung Hee Kho-
dc.contributor.authorTae Kwang Oh-
dc.contributor.authorChoong Hwan Lee-
dc.date.accessioned2017-04-19T09:01:43Z-
dc.date.available2017-04-19T09:01:43Z-
dc.date.issued2004-
dc.identifier.issn0006-3592-
dc.identifier.uri10.1002/bit.20189ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6677-
dc.description.abstractInhibitors of melanin biosynthesis were screened by using three different methods. The extract of Veratrum patulum contains hydroxystilbene compounds that are potent tyrosinase inhibitors. We evaluated the enzyme inhibitory property on the mushroom tyrosinase of hydroxystilbene compounds including resveratrol, oxyresveratrol, and their analogs. Biotransformation using cellulase of the whole extract brought about an increase in the inhibitory activity of the products on mushroom tyrosinase. The enhancement of tyrosinase inhibition is supposed to increase the concentration of aglycon, which has superior inhibitory activity to its glycoside. Eventually, melanin biosynthesis was inhibited by the enhanced tyrosinase inhibitory activity of the extract. This result indicated that deglycosylation of stilbene compounds has exerted more effective inhibition on the enzyme than that of the unprocessed plant extract.-
dc.publisherWiley-
dc.titleEnhancement of tyrosinase inhibition of the extract of Veratrum patulum using cellulase-
dc.title.alternativeEnhancement of tyrosinase inhibition of the extract of Veratrum patulum using cellulase-
dc.typeArticle-
dc.citation.titleBiotechnology and Bioengineering-
dc.citation.number7-
dc.citation.endPage854-
dc.citation.startPage849-
dc.citation.volume87-
dc.contributor.affiliatedAuthorDong Hyun Kim-
dc.contributor.affiliatedAuthorJin Hee Kim-
dc.contributor.affiliatedAuthorSeung Hwa Baek-
dc.contributor.affiliatedAuthorYung Hee Kho-
dc.contributor.affiliatedAuthorTae Kwang Oh-
dc.contributor.affiliatedAuthorChoong Hwan Lee-
dc.contributor.alternativeName김동현-
dc.contributor.alternativeName김진희-
dc.contributor.alternativeName백승화-
dc.contributor.alternativeName서진호-
dc.contributor.alternativeName고영희-
dc.contributor.alternativeName오태광-
dc.contributor.alternativeName이충환-
dc.identifier.bibliographicCitationBiotechnology and Bioengineering, vol. 87, no. 7, pp. 849-854-
dc.identifier.doi10.1002/bit.20189-
dc.subject.keywordBiotransformation-
dc.subject.keywordCellulase-
dc.subject.keywordResveratrol-
dc.subject.keywordTyrosinase inhibitor-
dc.subject.keywordVeratrum patulum-
dc.subject.localbiotransformation-
dc.subject.localBiotransformation-
dc.subject.localCellulase-
dc.subject.localcellulase-
dc.subject.localResveratrol-
dc.subject.localresveratrol-
dc.subject.localtyrosinase inhibitor-
dc.subject.localTyrosinase inhibitor-
dc.subject.localVeratrum patulum-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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