Ameliorating effect of the root extract from Platycodon grandiflorum on the ethanol-induced cognitive impairment in mice = 에탄올 투여로 유도한 생쥐의 인지기능 손상에 대한 길경 추출물의 개선효능

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Title
Ameliorating effect of the root extract from Platycodon grandiflorum on the ethanol-induced cognitive impairment in mice = 에탄올 투여로 유도한 생쥐의 인지기능 손상에 대한 길경 추출물의 개선효능
Author(s)
Y S Kim; J S Kim; Y H Choi; J H Seo; J W Lee; S K Kim; J S Kang; Hyun Sun Lee; Y S Cho; S H Roh; Y C Jeong; K H Shim; S Y Ryu
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 35, no. 3, pp. 239-243
Publication Year
2004
Abstract
The ameliorating effect of the MeOH extract of the root of Platycodon grandiflorum on the ethanol-induced cognitive dysfunction in mice was investigated. The total MeOH extract was devided into two fractions, saponin rich fraction and non-saponin fraction. The mice with repeated administration of the total MeOH extract and those with saponin rich fraction both showed a markedly prolonged latency time upon the step-through test (passive avoidance performance) performed after acute ethanol intoxication, while those with non-saponin rich fraction did not. The results suggest that the extracts from the root of Platycodon grandiflorum exert a beneficial effect on ethanol-induced memory impairment in mice and also suggest that these effects of the extracts might be ascribed to the saponin constituents.
Keyword
cognitive dysfunctionmemorypassive avoidance performanceplatycodon grandiflorumstep-through test
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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