DC Field | Value | Language |
---|---|---|
dc.contributor.author | E J Moon | - |
dc.contributor.author | C H Jeong | - |
dc.contributor.author | J W Jeong | - |
dc.contributor.author | K R Kim | - |
dc.contributor.author | Dae Yeul Yu | - |
dc.contributor.author | S Murakami | - |
dc.contributor.author | C W Kim | - |
dc.contributor.author | K W Kim | - |
dc.date.accessioned | 2017-04-19T09:01:44Z | - |
dc.date.available | 2017-04-19T09:01:44Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6684 | - |
dc.description.abstract | Hepatitis B virus X protein (HBx) is closely involved in the development of hepatocellular carcinoma, a highly vascularized solid tumor. Here we show that HBx increases the transcriptional activity and protein level of hypoxia-inducible factor-1alpha (HIF-1alpha) under both normoxic and hypoxic conditions, and it also stimulates angiogenesis. HBx directly interacted with the bHLH/PAS domain of HIF-1alpha but not with the von Hippel-Lindau protein (pVHL). HBx decreased the binding of pVHL to HIF-1alpha and prevented ubiquitin-dependent degradation of HIF-1alpha. In HBx-transgenic mice, HIF-1alpha and vascular endothelial growth factor were strongly detected in the dysplastic lesion, where HBx was also more highly expressed than in the non-neoplastic region of the liver. An immunohistochemical study showed that microvessels are more abundant in the dysplastic lesion than in the non-neoplastic region. Our data suggest that HBx stabilizes HIF-1alpha and leads to angiogenesis during hepatocarcinogenesis. | - |
dc.publisher | Wiley | - |
dc.title | Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1α | - |
dc.title.alternative | Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1α | - |
dc.type | Article | - |
dc.citation.title | FASEB Journal | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 384 | - |
dc.citation.startPage | 382 | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Dae Yeul Yu | - |
dc.contributor.alternativeName | 문은정 | - |
dc.contributor.alternativeName | 정철호 | - |
dc.contributor.alternativeName | 정주원 | - |
dc.contributor.alternativeName | 김광록 | - |
dc.contributor.alternativeName | 유대열 | - |
dc.contributor.alternativeName | Murakami | - |
dc.contributor.alternativeName | 김철우 | - |
dc.contributor.alternativeName | 김규원 | - |
dc.identifier.bibliographicCitation | FASEB Journal, vol. 18, no. 2, pp. 382-384 | - |
dc.identifier.doi | 10.1096/fj.03-0153fje | - |
dc.description.journalClass | Y | - |
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