Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1α

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dc.contributor.authorE J Moon-
dc.contributor.authorC H Jeong-
dc.contributor.authorJ W Jeong-
dc.contributor.authorK R Kim-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorS Murakami-
dc.contributor.authorC W Kim-
dc.contributor.authorK W Kim-
dc.date.accessioned2017-04-19T09:01:44Z-
dc.date.available2017-04-19T09:01:44Z-
dc.date.issued2004-
dc.identifier.issn0892-6638-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6684-
dc.description.abstractHepatitis B virus X protein (HBx) is closely involved in the development of hepatocellular carcinoma, a highly vascularized solid tumor. Here we show that HBx increases the transcriptional activity and protein level of hypoxia-inducible factor-1alpha (HIF-1alpha) under both normoxic and hypoxic conditions, and it also stimulates angiogenesis. HBx directly interacted with the bHLH/PAS domain of HIF-1alpha but not with the von Hippel-Lindau protein (pVHL). HBx decreased the binding of pVHL to HIF-1alpha and prevented ubiquitin-dependent degradation of HIF-1alpha. In HBx-transgenic mice, HIF-1alpha and vascular endothelial growth factor were strongly detected in the dysplastic lesion, where HBx was also more highly expressed than in the non-neoplastic region of the liver. An immunohistochemical study showed that microvessels are more abundant in the dysplastic lesion than in the non-neoplastic region. Our data suggest that HBx stabilizes HIF-1alpha and leads to angiogenesis during hepatocarcinogenesis.-
dc.publisherWiley-
dc.titleHepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1α-
dc.title.alternativeHepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1α-
dc.typeArticle-
dc.citation.titleFASEB Journal-
dc.citation.number2-
dc.citation.endPage384-
dc.citation.startPage382-
dc.citation.volume18-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.alternativeName문은정-
dc.contributor.alternativeName정철호-
dc.contributor.alternativeName정주원-
dc.contributor.alternativeName김광록-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeNameMurakami-
dc.contributor.alternativeName김철우-
dc.contributor.alternativeName김규원-
dc.identifier.bibliographicCitationFASEB Journal, vol. 18, no. 2, pp. 382-384-
dc.identifier.doi10.1096/fj.03-0153fje-
dc.description.journalClassY-
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