Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e

Cited 29 time in scopus
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Title
Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e
Author(s)
E K Joo; H E Broxmeyer; H J Kwon; H B Kang; J S Kim; Jong-Seok Lim; Yong Kyung Choe; In Seong Choe; P K Myung; Y H Lee
Bibliographic Citation
Stem Cells and Development, vol. 13, no. 5, pp. 563-570
Publication Year
2004
Abstract
Stromal cell-derived factor-1 (SDF-1/CXCL12) enhances the survival of hematopoietic stem and progenitor cells in synergy with other cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF), steel factor, and thrombopoietin (TPO), and both the PI3K/Akt and MAPK pathways have been linked to this survival. To further evaluate intracellular signaling involved in SDF-1/CXCL12 survival effects, we investigated modulation of downstream signaling molecules. The synergistic survival enhancement of SDF-1/CXCL12 plus other cytokines were directly linked to enhanced phosphorylation of p70/85S6K and cAMP responsive element binding protein (CREB), as well as enhanced induction of the Bcl-2 family member Mcl-1. Most prominently, c-Fos, a component of AP1 transcription factor, was synergistically induced by SDF-1/CXCL12 plus other cytokines. These results suggest that SDF-1/CXCL12 enhanced cell survival in synergy with other cytokines involves activation of CREB and induction of Mcl-1 and c-Fos.
ISSN
1525-8165
Publisher
Mary Ann Liebert, Inc
DOI
http://dx.doi.org/10.1089/scd.2004.13.563
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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