Identification of B-cell translocation gene 1 as a biomarker for monitoring the remission of acute myeloid leukemia

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Title
Identification of B-cell translocation gene 1 as a biomarker for monitoring the remission of acute myeloid leukemia
Author(s)
J W Cho; Jeong Jung Kim; Sung Goo Park; Do Hee Lee; Sang Chul Lee; H J Kim; Byoung Chul Park; S Y Cho
Bibliographic Citation
Proteomics, vol. 4, no. 11, pp. 3456-3463
Publication Year
2004
Abstract
Acute myeloid leukemia (AML) is a biologically heterogeneous disease of the hematopoietic system characterized by a clonal accumulation of immature blast cells in bone marrow. We used a proteomic approach based on two-dimensional electrophoresis and mass spectrometry to search for biomarkers related to the complete remission (CR) state of AML patients. We detected one AML-related protein, which was identified as the B-cell translocation gene 1 (BTG1) protein that belongs to anti-proliferative protein family. In the CR state of AML-M2 and M3 patients (by French-American-British subtype classification), the BTG1 protein was upregulated in bone marrow mononuclear cells. It was also expressed robustly in normal bone marrow mononuclear cells. In addition, the BTG1 levels in AML-M2 patients in a non-remission state after therapy did not increase as they did before therapy. Overexpression of BTG1 mRNA was also observed in the CR state of all-trans-retinoic acid (ATRA)-treated AML-M3 patients and ATRA-treated HL-60 cells. Taken together, these results suggest that BTG1 may play a role in the differentiation process of myeloid cells and can therefore be used as a potential treatment-related biomarkerfor monitoring the remission status of AML-M2 and M3 patients.
Keyword
Acute myeloid leukemiaAll-trans-retionic acidB-cell translocation geneDifferentiation
ISSN
1615-9853
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/pmic.200400968
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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