7-oxostaurosporine selectively inhibits the mycelial forum of Candida albicans

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Title
7-oxostaurosporine selectively inhibits the mycelial forum of Candida albicans
Author(s)
E I Hwang; Bong Sik Yun; Sang-Han Lee; S K Kim; S J Lim; Sung Uk Kim
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 14, no. 5, pp. 1067-1070
Publication Year
2004
Abstract
In the course of screening for specific inhibitors against the mycelial form of Candida albicans from natural resources, we have isolated and identified A6792-1 from Streptomyces sp. A6792 by using several chromatographies. By spectral analyses, this compound was determined as 7-oxostaurosporine, having a structure of staurosporine aglycon moiety. 7-Oxostaurosporine exhibited a selective growth inhibitory activity against the mycelial form of Candida spp. up to 100 μg/disc in bioassay. It also exhibited a specific antifungal activity against the mycelial form of Candida spp. including C. krusei, C. albicans, C. tropicalis, and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. Therefore, this compound may have a considerable potential as an antifungal agent based on the preferential inhibition against growth of the mycelial form of Candida spp., dimorphic fungi.
Keyword
7-oxostaurosporinecandida albicansmorphological transition7 oxostaurosporine
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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