Identification of target proteins of N-acetylglucosaminyl-transferase V and fucosyltransferase 8 in human gastric tissues by glycomic approach

Cited 18 time in scopus
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Title
Identification of target proteins of N-acetylglucosaminyl-transferase V and fucosyltransferase 8 in human gastric tissues by glycomic approach
Author(s)
Yong Sam Kim; Soo Young Hwang; S J Oh; Hosung Sohn; Hye Yeon Kang; J H Lee; Eun Wie Cho; J Y Kim; J S Yoo; Nam-Soon Kim; C H Kim; E Miyoshi; N Taniguchi; Jeong Heon Ko
Bibliographic Citation
Proteomics, vol. 4, no. 11, pp. 3353-3358
Publication Year
2004
Abstract
To understand better the mechanism underlying gastric cancer and search for potential markers for gastric cancer prognosis, the proteomic analysis of gastric cancer tissues was conducted using two-dimensional gel electrophoresis and lectin blot, followed by electrospray ionization-mass spectrometry. These approaches permitted identification of glyco- or putative glycosylated proteins which may be associated with tumorigenesis. The proteins identified include molecules involved in sugar metabolism, signal transduction, proteolysis, and stress, as well as several unknown proteins, which were aberrantly glycosylated as evidenced by the L-phytohemagglutinin blot.
Keyword
Gastric cancerGlycosylationLectinN-acetylglucosaminyltransferaseTwo-dimensional gel electrophoresis
ISSN
1615-9853
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/pmic.200401026
Type
Article
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > Genome Editing Research Center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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