Effect of the hesperetin and naringenin on pp60v-src -induced NF-κB activation = pp60v-src에 의한 NF-κB 활성화에 대한 헤스페리틴과 나린제닌의 저해 효과

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Title
Effect of the hesperetin and naringenin on pp60v-src -induced NF-κB activation = pp60v-src에 의한 NF-κB 활성화에 대한 헤스페리틴과 나린제닌의 저해 효과
Author(s)
O Song Kwon; Bo Yeon Kim; Kyoung A Kim; Min Soo Kim; Hyuncheol Oh; Beom Seok Kim; Y H Kim; Jong Seog Ahn
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 35, no. 3, pp. 244-249
Publication Year
2004
Abstract
The effects of hesperetin and naringenin on NF-κB activation were investigated in normal rat kidney cells transformed by temperature sensitive Rous Sarcoma Virus (tsNRK). The flavonoids, naringenin and hesperetin, significantly reduced v-Src-induced NF-κB activation as well as phosphorylation of Akt and GSK-3 in tsNRK cells, whereas these compounds did not effect on platelet-derived growth factor (PDGF)-induced NF-κB activation in NIH3T3γ1 cells. In addition, the DNA binding activity of SP-1 was also reduced but that of AP-1 was not affected by the compounds. Our study suggests that Src-induced NF-κB activation could occur via Akt-GSK-3 pathway without IκBα degradation and that naringenin and hesperetin could be used in the treatment of cancer through the inhibition of NF-κB activation.
Keyword
AktflavonoidGSK-3hesperetinIκBαnaringeninNF-κBv-Src
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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