The effect of 5-substitution on the cytotoxicity of 2-(p-methoxyphenyl)-1H-benzimidazoles in human cancer cell lines

Cited 0 time in scopus
Metadata Downloads
Title
The effect of 5-substitution on the cytotoxicity of 2-(p-methoxyphenyl)-1H-benzimidazoles in human cancer cell lines
Author(s)
M J Kwon; Hwan Mook Kim; D D Kim; J S Kim
Bibliographic Citation
Key Engineering Materials, vol. 277, no. 1, pp. 23-27
Publication Year
2005
Abstract
A series of 5-substituted 2-(p-methoxyphenyl)-1H-benzimidazoles was synthesized and evaluated for cytotoxicity against 4 human cancer cell lines, HCT 15, PC-3, A549, and ACHN. Except for the 5-chloro analogue, most of the 5-substituted compounds showed significant cytotoxicities in these cell lines. However, the structure activity relationship study revealed that neither the electronic nor the lipophilic parameters of the 5-substituents were related to cytotoxicity. Moreover, none of the analogues showed significant NF K-β inhibition activity implying that cytotoxicity was not related to this mechanism. The 5-methyl analogue was the most potent compound in this series with a GI50 of 0.9 μM in the A549 cell line.
Keyword
structure activity relationship2-(p-methoxyphenyl)-1h-benzimidazolecytotoxicityNF K-β inhibition
ISSN
1013-9826
Publisher
Trans Tech Publications
DOI
http://dx.doi.org/10.4028/www.scientific.net/KEM.277-279.23
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.