Caffeine이 N-bis(2-hydroxypropyl)nitrosamine과 sulfadimethoxine에 의해 유발된 갑상선 피막의 섬유성 증식에 미치는 영향

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dc.contributor.authorH Y Son-
dc.contributor.authorWoon Kee Yoon-
dc.contributor.authorY H Jee-
dc.contributor.authorS Y Ryu-
dc.contributor.authorJ R Kim-
dc.contributor.authorS W Cho-
dc.date.accessioned2017-04-19T09:01:55Z-
dc.date.available2017-04-19T09:01:55Z-
dc.date.issued2003-
dc.identifier.issn12250198-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6720-
dc.description.abstractCaffeine (1,3,7-trimethylxanthine), a central nervous system stimulant, is contained in various foods, beverages and over-the-counter medications. Sulfadimethoxine (SDM) is one of the anti-thyroid agents and induces proliferation of thyroid capsule in two stage thyroid carcinogenesis model using N-bis(2-hydroxypropyl)nitrosamine (DHPN). In this study, we examined the effect of caffeine on fibrous proliferation of thyroid capsule in DHPN and SDM-treated rats. Five-week-old male F344 rats were given a single subcutaneous injection of DHPN (2,800 mg/kg, body weight). Starting one week thereafter, SDM (1,000 ppm in drinking water) with or without caffeine (1,500 ppm in diet) was administered for 12 weeks. All animals were autopsied and histopathological examination of the thyroid glands was performed. Thyroid follicular proliferative changes were induced in all rats treated with DHPN+SDM. In addition, the proliferation of perithyroidal fibrous tissue and pleomorphic thyroid follicular cells within the capsule were observed in DHPN+SDM treated group. Caffeine would not be related to these lesions in this experimental condition, although pentoxifylline, a methylxanthine derivative, has an antifibrotic effects.-
dc.publisherSouth Korea-
dc.titleCaffeine이 N-bis(2-hydroxypropyl)nitrosamine과 sulfadimethoxine에 의해 유발된 갑상선 피막의 섬유성 증식에 미치는 영향-
dc.title.alternativeEffects of caffeine on capsular fibrous proliferation induced by N-bis(2-hydroxyprophyl)nitrosamine and sulfadimethoxine in the thyroid glands-
dc.typeArticle-
dc.citation.titleKorean Journal of Veterinary Research-
dc.citation.number4-
dc.citation.endPage688-
dc.citation.startPage683-
dc.citation.volume43-
dc.contributor.affiliatedAuthorWoon Kee Yoon-
dc.contributor.alternativeName손화영-
dc.contributor.alternativeName윤원기-
dc.contributor.alternativeName지영흔-
dc.contributor.alternativeName류시윤-
dc.contributor.alternativeName김정란-
dc.contributor.alternativeName조성환-
dc.identifier.bibliographicCitationKorean Journal of Veterinary Research, vol. 43, no. 4, pp. 683-688-
dc.subject.keywordcaffeine-
dc.subject.keywordsulfadimethoxine-
dc.subject.keywordcapsular fibrosis-
dc.subject.keywordhistopathology-
dc.subject.localcaffeine-
dc.subject.localCaffeine-
dc.subject.localsulfadimethoxine-
dc.subject.localcapsular fibrosis-
dc.subject.localhistopathology-
dc.subject.localHistopathology-
dc.description.journalClassN-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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