Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense

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dc.contributor.authorHyuncheol Oh-
dc.contributor.authorD H Kim-
dc.contributor.authorJ H Cho-
dc.contributor.authorY C Kim-
dc.date.accessioned2017-04-19T09:01:56Z-
dc.date.available2017-04-19T09:01:56Z-
dc.date.issued2004-
dc.identifier.issn0378-8741-
dc.identifier.uri10.1016/j.jep.2004.08.015ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6728-
dc.description.abstractHepatoprotective activity-guided fractionation of the MeOH extract of Equisetum arvense L. (Equisetaceae) resulted in the isolation of two phenolic petrosins, onitin (1) and onitin-9-O-glucoside (2), along with four flavonoids, apigenin (3), luteolin (4), kaempferol-3-O-glucoside (5), and quercetin-3-O-glucoside (6). Among these, compounds 1 and 4 exhibited hepatoprotective activities on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells, displaying EC50 values of 85.8 ± 9.3 μM and 20.2 ± 1.4 μM, respectively. Silybin, used as a positive control, showed the EC50 value of 69.0 ± 3.3 μM. Compounds 1 and 4 also showed superoxide scavenging effects (IC50 = 35.3 ± 0.2 μM and 5.9 ± 0.3 μM, respectively) and DPPH free radical scavenging effect (IC50 of 35.8 ± 0.4 μM and 22.7 ± 2.8 μM, respectively). These results support the use of this plant for the treatment of hepatitis in oriental traditional medicine.-
dc.publisherElsevier-
dc.titleHepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense-
dc.title.alternativeHepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense-
dc.typeArticle-
dc.citation.titleJournal of Ethnopharmacology-
dc.citation.number2-
dc.citation.endPage424-
dc.citation.startPage421-
dc.citation.volume95-
dc.contributor.affiliatedAuthorHyuncheol Oh-
dc.contributor.alternativeName오현철-
dc.contributor.alternativeName김도훈-
dc.contributor.alternativeName조정희-
dc.contributor.alternativeName김연철-
dc.identifier.bibliographicCitationJournal of Ethnopharmacology, vol. 95, no. 2, pp. 421-424-
dc.identifier.doi10.1016/j.jep.2004.08.015-
dc.subject.keywordAntioxidants-
dc.subject.keywordEquisetum arvense-
dc.subject.keywordFlavonoids-
dc.subject.keywordHepatoprotective-
dc.subject.keywordPhenolic petrosins-
dc.subject.localAntioxidants-
dc.subject.localantioxidant-
dc.subject.localAnti-oxidant-
dc.subject.localantioxidants-
dc.subject.localANTIOXIDANT-
dc.subject.localanti-oxidants-
dc.subject.localAntioxidant-
dc.subject.localEquisetum arvense-
dc.subject.localFlavonoids-
dc.subject.localflavonoid-
dc.subject.localflavonoids-
dc.subject.localFlavonoid-
dc.subject.localHepatoprotective-
dc.subject.localhepatoprotective-
dc.subject.localPhenolic petrosins-
dc.description.journalClassY-
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