An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa

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Title
An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes from Agrimonia pilosa
Author(s)
E J Park; Hyuncheol Oh; T H Kang; D H Sohn; Y C Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 27, no. 9, pp. 944-946
Publication Year
2004
Abstract
Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-β-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC50 values of 88.2 ± 2.8 and 37.7 ± 1.6 μM, respectively.
Keyword
agrimonia pilosaagrimonolidehepatoprotectiveisocoumarinrosaceae
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02975848
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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