Isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum

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Title
Isolation of angiotensin converting enzyme (ACE) inhibitory flavonoids from Sedum sarmentosum
Author(s)
Hyuncheol Oh; D G Kang; J W Kwon; T O Kwon; S Y Lee; D B Lee; H S Lee
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 27, no. 12, pp. 2035-2037
Publication Year
2004
Abstract
Bioassay-guided fractionation of the EtOAc-soluble extract of Sedum sarmentosum afforded a new flavonoid, quercetin-3-O-α-(6?- caffeoylglucosyl-β-1,2-rhamnoside) (1), along with four known flavonoids, quercetin 3-O-α-(6?-p-coumaroylglucosyl-β-1,2-rhamnoside) (2), isorhamnetin-3-β-glucopyranoside (3), quercetin-3-β-glucopyranoside (4), and kaempferol-3-α-arabinopyranoside (5). Purification of these compounds was conducted with the application of various chromatographic methods. Compounds 1-5 inhibited angiotensin I converting enzyme (ACE) activity in a concentration-dependent manner. Compounds 1-5 had 50% inhibitory concentration values of 158.9±11.1 μM, 351.6±3.9 μM, 408.9±4.6 μM, 708.8±23.1 μM, and 392.8±13.4 μM.
Keyword
Angiotensin converting enzyme (ACE)InhibitorSedum sarmentosum
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.27.2035
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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