Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Uncaria sinensis Havil

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Title
Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Uncaria sinensis Havil
Author(s)
M Na; Y H Kim; Byung Sun Min; K Bae; Y Kamiryo; Y Senoo; S Yokoo; N Miwa; K S Song; Y H Seong
Bibliographic Citation
Journal of Ethnopharmacology, vol. 95, no. 2, pp. 127-132
Publication Year
2004
Abstract
The ethanol extract from the hooks and stems of Uncaria sinensis Havil (Rubiaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length. In the peroxidation model using t-BuOOH, the Uncaria sinensis extract showed a notable cytoprotective effect on the HEK-N/F cells with 65.0 ± 3.0% of cell viability when compared with control cells at a concentration of 50 μg/ml. In addition, the Uncaria sinensis extract exhibited a significant cytoprotective effect against UVB-induced oxidative damage. The life-span of the HEK-N/F cells was elongated by 201% as a result of the continuous administration of 3 μg/ml of the Uncaria sinensis extract compared to that of the control. These observations were attributed to the inhibitory effect of the Uncaria sinensis extract on the age-dependent shortening of the telomere length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages.
Keyword
Oxidative stressRubiaceaeSouthern blotsTelomere lengthUncaria sinensis Havil
ISSN
0378-8741
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jep.2004.06.027
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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