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- Title
- Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Uncaria sinensis Havil
- Author(s)
- M Na; Y H Kim; Byung Sun Min; K Bae; Y Kamiryo; Y Senoo; S Yokoo; N Miwa; K S Song; Y H Seong
- Bibliographic Citation
- Journal of Ethnopharmacology, vol. 95, no. 2, pp. 127-132
- Publication Year
- 2004
- Abstract
- The ethanol extract from the hooks and stems of Uncaria sinensis Havil (Rubiaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length. In the peroxidation model using t-BuOOH, the Uncaria sinensis extract showed a notable cytoprotective effect on the HEK-N/F cells with 65.0 ± 3.0% of cell viability when compared with control cells at a concentration of 50 μg/ml. In addition, the Uncaria sinensis extract exhibited a significant cytoprotective effect against UVB-induced oxidative damage. The life-span of the HEK-N/F cells was elongated by 201% as a result of the continuous administration of 3 μg/ml of the Uncaria sinensis extract compared to that of the control. These observations were attributed to the inhibitory effect of the Uncaria sinensis extract on the age-dependent shortening of the telomere length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages.
- Keyword
- Oxidative stressRubiaceaeSouthern blotsTelomere lengthUncaria sinensis Havil
- ISSN
- 0378-8741
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.jep.2004.06.027
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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