Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit

Cited 41 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorM Na-
dc.contributor.authorK Bae-
dc.contributor.authorS S Kang-
dc.contributor.authorByung Sun Min-
dc.contributor.authorJ K Yoo-
dc.contributor.authorY Kamiryo-
dc.contributor.authorY Senoo-
dc.contributor.authorS Yokoo-
dc.contributor.authorN Miwa-
dc.date.accessioned2017-04-19T09:02:02Z-
dc.date.available2017-04-19T09:02:02Z-
dc.date.issued2004-
dc.identifier.issn0951-418X-
dc.identifier.uri10.1002/ptr.1529ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6760-
dc.description.abstractThe ethanol extract from the fruit of Terminalia chebula (Combretaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length. In the peroxidation model using t-BuOOH, the T. chebula extract showed a notable cytoprotective effect on the HEK-N/F cells with 60.5 ± 3.8% at a concentration of 50 μg/ml. In addition, the T. chebula extract exhibited a significant cytoprotective effect against UVB-induced oxidative damage. The life-span of the HEK-N/F cells was elongated by 40% as a result of the continuous administration of 3 μg/ml of the T. chebula extract compared to that of the control. These observations were attributed to the inhibitory effect of the T. chebula extract on the age-dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages.-
dc.publisherWiley-
dc.titleCytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit-
dc.title.alternativeCytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit-
dc.typeArticle-
dc.citation.titlePhytotherapy Research-
dc.citation.number9-
dc.citation.endPage741-
dc.citation.startPage737-
dc.citation.volume18-
dc.contributor.affiliatedAuthorByung Sun Min-
dc.contributor.alternativeName나민균-
dc.contributor.alternativeName배기환-
dc.contributor.alternativeName강삼식-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeName유재국-
dc.contributor.alternativeNameKamiryo-
dc.contributor.alternativeNameSenoo-
dc.contributor.alternativeNameYokoo-
dc.contributor.alternativeNameMiwa-
dc.identifier.bibliographicCitationPhytotherapy Research, vol. 18, no. 9, pp. 737-741-
dc.identifier.doi10.1002/ptr.1529-
dc.subject.keywordCombretaceae-
dc.subject.keywordOxidative stress-
dc.subject.keywordSouthern blots-
dc.subject.keywordTelomere length-
dc.subject.keywordTerminalia chebula-
dc.subject.localCombretaceae-
dc.subject.localOxidative stre-
dc.subject.localOxidative stress-
dc.subject.localOXIDATIVE STRESS-
dc.subject.localOxidative Stress-
dc.subject.localoxidative stress-
dc.subject.localSouthern blot-
dc.subject.localsouthern blot-
dc.subject.localSouthern blots-
dc.subject.localTelomere length-
dc.subject.localTerminalia chebula-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.