Anti-complement activity of norlignans and terpenes from the stem bark of Styrax japonica

Cited 41 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorByung Sun Min-
dc.contributor.authorSei Ryang Oh-
dc.contributor.authorKyung Seop Ahn-
dc.contributor.authorJung Hee Kim-
dc.contributor.authorJoongku Lee-
dc.contributor.authorDoo-Young Kim-
dc.contributor.authorE H Kim-
dc.contributor.authorHyeong Kyu Lee-
dc.date.accessioned2017-04-19T09:02:04Z-
dc.date.available2017-04-19T09:02:04Z-
dc.date.issued2004-
dc.identifier.issn0032-0943-
dc.identifier.uri10.1055/s-2004-835853ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6774-
dc.description.abstractA new norlignan, styraxlignolide A (1), and two new terpenes, styraxosides A (2) and B (3), were isolated from the MeOH-soluble fraction of Styrax japonica Sieb. et Zucc. (Styracaceae) stem bark, together with two known compounds, egonol (4) and masutakeside I (5). The new compounds were determined as 5-(3″-hydroxypropyl)-7-methoxy-2-(3′,4′-dimethoxyphenyl) -benzofuran 3″-O-[β-D-xylopyranoside-(1→6)-β-D- glucopyranoside] (1), 3β,7β-dihydroxy-4α,4β,8β, 10β,14α-pentamethyl-5α-gon-16-en-2-one 3-O-[β-D- glucopyranoside-(1→2)-β-D-glucopyranoside] (2), and 3β,17β-dihydroxy-28-norolean-12-en-16-one 3-O-[α-L- rhamopyranoside-(1→2)-β-D-glucuronopyranoside] (3) by spectroscopic means including 2D-NMR. The five compounds were tested in vitro for anti-complement activity against the complement system. Compounds 1, 3, 4, and 5 displayed inhibitory activity in the anti-complement assay, with IC 50 values of 123, 65, 33, and 166 μM, respectively. Compound 1a and camellenodiol (3a), obtained from acid hydrolysis of 1 and 3, respectively, did not affect the hemolytic activity of human serum against sensitized erythrocytes. This shows that a sugar seems to play a role of enhancing significantly anti-complement activity.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleAnti-complement activity of norlignans and terpenes from the stem bark of Styrax japonica-
dc.title.alternativeAnti-complement activity of norlignans and terpenes from the stem bark of Styrax japonica-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number12-
dc.citation.endPage1215-
dc.citation.startPage1210-
dc.citation.volume70-
dc.contributor.affiliatedAuthorByung Sun Min-
dc.contributor.affiliatedAuthorSei Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.affiliatedAuthorJung Hee Kim-
dc.contributor.affiliatedAuthorJoongku Lee-
dc.contributor.affiliatedAuthorDoo-Young Kim-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName안경섭-
dc.contributor.alternativeName김정희-
dc.contributor.alternativeName이중구-
dc.contributor.alternativeName김두영-
dc.contributor.alternativeName김은희-
dc.contributor.alternativeName이형규-
dc.identifier.bibliographicCitationPlanta Medica, vol. 70, no. 12, pp. 1210-1215-
dc.identifier.doi10.1055/s-2004-835853-
dc.subject.keywordAnti-complement activity-
dc.subject.keywordEgonol-
dc.subject.keywordNorlignan-
dc.subject.keywordOctanordammarane noroleanane-
dc.subject.keywordStyracaceae-
dc.subject.keywordStyrax japonica-
dc.subject.localanti-complement activity-
dc.subject.localAnti-complement activity-
dc.subject.localanticomplement activity-
dc.subject.localAnticomplement activity-
dc.subject.localEgonol-
dc.subject.localNorlignan-
dc.subject.localOctanordammarane noroleanane-
dc.subject.localStyracaceae-
dc.subject.localstyracaceae-
dc.subject.localStyrax japonica-
dc.subject.localstyrax japonica-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.