Anti-complement activity of norlignans and terpenes from the stem bark of Styrax japonica

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Anti-complement activity of norlignans and terpenes from the stem bark of Styrax japonica
Byung Sun Min; Sei Ryang OhKyung Seop AhnJung Hee Kim; Joongku Lee; Doo-Young Kim; E H Kim; Hyeong Kyu Lee
Bibliographic Citation
Planta Medica, vol. 70, no. 12, pp. 1210-1215
Publication Year
A new norlignan, styraxlignolide A (1), and two new terpenes, styraxosides A (2) and B (3), were isolated from the MeOH-soluble fraction of Styrax japonica Sieb. et Zucc. (Styracaceae) stem bark, together with two known compounds, egonol (4) and masutakeside I (5). The new compounds were determined as 5-(3″-hydroxypropyl)-7-methoxy-2-(3′,4′-dimethoxyphenyl) -benzofuran 3″-O-[β-D-xylopyranoside-(1→6)-β-D- glucopyranoside] (1), 3β,7β-dihydroxy-4α,4β,8β, 10β,14α-pentamethyl-5α-gon-16-en-2-one 3-O-[β-D- glucopyranoside-(1→2)-β-D-glucopyranoside] (2), and 3β,17β-dihydroxy-28-norolean-12-en-16-one 3-O-[α-L- rhamopyranoside-(1→2)-β-D-glucuronopyranoside] (3) by spectroscopic means including 2D-NMR. The five compounds were tested in vitro for anti-complement activity against the complement system. Compounds 1, 3, 4, and 5 displayed inhibitory activity in the anti-complement assay, with IC 50 values of 123, 65, 33, and 166 μM, respectively. Compound 1a and camellenodiol (3a), obtained from acid hydrolysis of 1 and 3, respectively, did not affect the hemolytic activity of human serum against sensitized erythrocytes. This shows that a sugar seems to play a role of enhancing significantly anti-complement activity.
Anti-complement activityEgonolNorlignanOctanordammarane noroleananeStyracaceaeStyrax japonica
Georg Thieme Verlag Kg
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Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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