Effects of caffeic acid methyl ester from Mentha arvensis Linne var. piperascens on function of E6 oncoprotein of HPV 16 = 박하에서 분리한 caffeic acid methyl ester가 자궁경부암 바이러스 발암단백질 E6의 기능에 미치는 영향

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dc.contributor.authorTae Woong Baek-
dc.contributor.authorKyung-Ae Lee-
dc.contributor.authorMinjung Ahn-
dc.contributor.authorHae Kyung Joo-
dc.contributor.authorHyuncheol Oh-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorY K Cho-
dc.contributor.authorP K Myung-
dc.contributor.authorDo Young Yoon-
dc.description.abstractCervical cancer is one of the leading causes of female death. Viral oncoproteins E6 and E7 are selectively retained and expressed in carcinoma cells infected with HPV (Human papillomavirus) type 16 and cooperated in immotalization and transformation of primary keratinocyte. E6 and E7 oncoproteins interact and interfere with the functions of tumor suppressor proteins p53 and retinoblasoma protein (pRb), respectively. Among a lots of natural products, Mentha arvensis Linne var. piperascens have inhibitory effects on the bindings between E6 oncoprotein and tumor suppressor p53, E3 ubiquitin-protein ligase (E6AP). HPV oncoprotein inhibitors from Mentha piperita L. were isolated by solvent partition and column chromatography (silica gel, RP-18) and inhibitory compounds were finally purified by HPLC using an ELISA screening system based on binding between E6 and E6AP. The aim of this study is to identify the structure of inhibitory compounds and investigate whether these compounds have inhibitory effects on functions of E6 oncoprotein. We investigated whether caffeic acid methyl ester (CAM) extracted from Mentha piperita L. could inhibit the function of E6 oncoprotein. CAM inhibited the in vitro binding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53 and also inhibited the proliferation of human cervical cancer cell lines (SiHa and CaSki) in a dose response manner. These result suggest that CAM inhibited the function of E6 oncoprotein, suggesting that it can be used as a potential drug for the treatment of cervical cancers infected with HPV.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleEffects of caffeic acid methyl ester from Mentha arvensis Linne var. piperascens on function of E6 oncoprotein of HPV 16 = 박하에서 분리한 caffeic acid methyl ester가 자궁경부암 바이러스 발암단백질 E6의 기능에 미치는 영향-
dc.title.alternativeEffects of caffeic acid methyl ester from Mentha arvensis Linne var. piperascens on function of E6 oncoprotein of HPV 16-
dc.citation.titleYakhak Hoeji-
dc.contributor.affiliatedAuthorTae Woong Baek-
dc.contributor.affiliatedAuthorKyung-Ae Lee-
dc.contributor.affiliatedAuthorMinjung Ahn-
dc.contributor.affiliatedAuthorHae Kyung Joo-
dc.contributor.affiliatedAuthorHyuncheol Oh-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorDo Young Yoon-
dc.identifier.bibliographicCitationYakhak Hoeji, vol. 48, no. 6, pp. 328-334-
dc.subject.keywordhuman papilloma virus (HPV)-
dc.subject.keywordmentha arvensis linne var. piperascens-
dc.subject.keywordE6 and Caffeic acid methyl ester-
dc.subject.localhuman papillomavirus (HPV)-
dc.subject.localHuman papillomavirus-
dc.subject.localhuman paillomavirus(HPV)-
dc.subject.localhuman papillomavirus-
dc.subject.localHuman papillomavirus (HPV)-
dc.subject.localhuman papilloma virus (HPV)-
dc.subject.localmentha arvensis linne var. piperascens-
dc.subject.localE6 and Caffeic acid methyl ester-
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