DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tae Sook Jeong | - |
dc.contributor.author | Kyung Soon Kim | - |
dc.contributor.author | Hana Yu | - |
dc.contributor.author | Mi Jeong Kim | - |
dc.contributor.author | Kyung Hyun Cho | - |
dc.contributor.author | Yang Kyu Choi | - |
dc.contributor.author | Hyoung-Chin Kim | - |
dc.contributor.author | Ho Yong Park | - |
dc.contributor.author | Woo Song Lee | - |
dc.date.accessioned | 2017-04-19T09:02:10Z | - |
dc.date.available | 2017-04-19T09:02:10Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | 10.1016/j.bmcl.2004.10.066 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6787 | - |
dc.description.abstract | A series of saucerneol B derivatives 2a-i were prepared for evaluating their acyl-CoA: cholesterol acyltransferase inhibitory activities. Compounds 2a-g showed more specificity of hACAT-1 than hACAT-2. Saucerneol B (1) exhibited strong cholesterol-lowering effect in high cholesterol-fed mice. A series of 2a-i were prepared from a lead compound, saucerneol B (1) for evaluating their acyl-CoA: cholesterol acyltransferase inhibitory activities. Compounds 2a-g exhibited the high specificity of hACAT-1 than hACAT-2, whereas 2h and 2i showed very weak inhibitory activities in both hACAT-1 and hACAT-2. Saucerneol B (1) exhibited strong cholesterol-lowering effect in high cholesterol-fed mice. | - |
dc.publisher | Elsevier | - |
dc.title | Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors | - |
dc.title.alternative | Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 388 | - |
dc.citation.startPage | 385 | - |
dc.citation.volume | 15 | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.affiliatedAuthor | Kyung Soon Kim | - |
dc.contributor.affiliatedAuthor | Hana Yu | - |
dc.contributor.affiliatedAuthor | Mi Jeong Kim | - |
dc.contributor.affiliatedAuthor | Kyung Hyun Cho | - |
dc.contributor.affiliatedAuthor | Yang Kyu Choi | - |
dc.contributor.affiliatedAuthor | Hyoung-Chin Kim | - |
dc.contributor.affiliatedAuthor | Ho Yong Park | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.contributor.alternativeName | 김경순 | - |
dc.contributor.alternativeName | 유하나 | - |
dc.contributor.alternativeName | 김미정 | - |
dc.contributor.alternativeName | 조경현 | - |
dc.contributor.alternativeName | 최양규 | - |
dc.contributor.alternativeName | 김형진 | - |
dc.contributor.alternativeName | 박호용 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 2, pp. 385-388 | - |
dc.identifier.doi | 10.1016/j.bmcl.2004.10.066 | - |
dc.subject.keyword | ACAT inhibitor | - |
dc.subject.local | ACAT inhibitor | - |
dc.subject.local | ACAT inhibitors | - |
dc.description.journalClass | Y | - |
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