Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors

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dc.contributor.authorTae Sook Jeong-
dc.contributor.authorKyung Soon Kim-
dc.contributor.authorHana Yu-
dc.contributor.authorMi Jeong Kim-
dc.contributor.authorKyung Hyun Cho-
dc.contributor.authorYang Kyu Choi-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorHo Yong Park-
dc.contributor.authorWoo Song Lee-
dc.date.accessioned2017-04-19T09:02:10Z-
dc.date.available2017-04-19T09:02:10Z-
dc.date.issued2005-
dc.identifier.issn0960-894X-
dc.identifier.uri10.1016/j.bmcl.2004.10.066ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6787-
dc.description.abstractA series of saucerneol B derivatives 2a-i were prepared for evaluating their acyl-CoA: cholesterol acyltransferase inhibitory activities. Compounds 2a-g showed more specificity of hACAT-1 than hACAT-2. Saucerneol B (1) exhibited strong cholesterol-lowering effect in high cholesterol-fed mice. A series of 2a-i were prepared from a lead compound, saucerneol B (1) for evaluating their acyl-CoA: cholesterol acyltransferase inhibitory activities. Compounds 2a-g exhibited the high specificity of hACAT-1 than hACAT-2, whereas 2h and 2i showed very weak inhibitory activities in both hACAT-1 and hACAT-2. Saucerneol B (1) exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.-
dc.publisherElsevier-
dc.titleSaucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors-
dc.title.alternativeSaucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number2-
dc.citation.endPage388-
dc.citation.startPage385-
dc.citation.volume15-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.affiliatedAuthorKyung Soon Kim-
dc.contributor.affiliatedAuthorHana Yu-
dc.contributor.affiliatedAuthorMi Jeong Kim-
dc.contributor.affiliatedAuthorKyung Hyun Cho-
dc.contributor.affiliatedAuthorYang Kyu Choi-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.affiliatedAuthorHo Yong Park-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName김경순-
dc.contributor.alternativeName유하나-
dc.contributor.alternativeName김미정-
dc.contributor.alternativeName조경현-
dc.contributor.alternativeName최양규-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName박호용-
dc.contributor.alternativeName이우송-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 15, no. 2, pp. 385-388-
dc.identifier.doi10.1016/j.bmcl.2004.10.066-
dc.subject.keywordACAT inhibitor-
dc.subject.localACAT inhibitor-
dc.subject.localACAT inhibitors-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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