Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus

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Title
Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus
Author(s)
Ick Dong Yoo; Kyung Mi Cho; C K Lee; Won Gon Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 2, pp. 353-356
Publication Year
2005
Abstract
A new seven-membered lactone type meroterpenoid, isoterreulactone A, was isolated from the solid state fermentation of Aspergillus terreus and its structure was established by various spectral analysis. Isoterreulactone A inhibited acetylcholinesterase with an IC50 value of 2.5 μM while did not inhibit butyrylcholinesterase even at 500 μM. A new seven-membered lactone type meroterpenoid, isoterreulactone A, was isolated from the solid state fermentation of Aspergillus terreus and its structure was established by various spectral analysis. Isoterreulactone A inhibited acetylcholinesterase with an IC50 value of 2.5 μM while did not inhibit butyrylcholinesterase even at 500 μM.
Keyword
Anti-acetylcholinesteraseMeroterpenoid
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2004.10.067
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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