Human endogenous retroviral elements belonging to the HERV-S family from human tissues, cancer cells, and primates: expression, structure, phylogeny and evolution

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dc.contributor.authorJ M Yi-
dc.contributor.authorT H Kim-
dc.contributor.authorJae Won Huh-
dc.contributor.authorK S Park-
dc.contributor.authorS B Jang-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorH S Kim-
dc.date.accessioned2017-04-19T09:02:11Z-
dc.date.available2017-04-19T09:02:11Z-
dc.date.issued2004-
dc.identifier.issn0378-1119-
dc.identifier.uri10.1016/j.gene.2004.08.007ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6793-
dc.description.abstractA new human endogenous retrovirus family (HERV-S) was recently identified from the human chromosome X. The HERV-S was 6.7 kb in length with typical retroviral structure (LTR-gag-pol-env-LTR). We investigated pol fragments of HERV-S family in various human tissues and cancer cells. The pol gene was expressed in only brain and thymus among human tissues (brain, prostate, testis, heart, kidney, liver, lung, placenta, skeletal muscle, spleen, thymus, uterus), whereas the pol gene was detected in various cancer cell lines (RT4, PFSK-1, BT-474, HCT-116, Jurkat, HepG2, MCF7, OVCAR-3, MIA-PaCa-2, PC3, LOX-IMVI, AZ521, 2F7, and C-33A) except for TE-1, UO-31, A549, and U-937 by RT-PCR analysis. Expression and sequencing data of the 33 clones imply that the pol gene of HERV-S family is more active in cancer cells than in human tissues, which may have transcriptional potential role related to various human cancers. Phylogenetic analysis of HERV-S pol family distinctively divided into three groups (group I, II, and III) through evolutionary divergence in primate evolution. Evolutionary divergence of the HERV-S family by PCR amplification and sequence analysis indicated that they were integrated into the primate genomes approximately 43 Myr ago and have been evolved rate of 0.3% nucleotide differences per Myr during primate evolution.-
dc.publisherElsevier-
dc.titleHuman endogenous retroviral elements belonging to the HERV-S family from human tissues, cancer cells, and primates: expression, structure, phylogeny and evolution-
dc.title.alternativeHuman endogenous retroviral elements belonging to the HERV-S family from human tissues, cancer cells, and primates: expression, structure, phylogeny and evolution-
dc.typeArticle-
dc.citation.titleGene-
dc.citation.number2-
dc.citation.endPage292-
dc.citation.startPage283-
dc.citation.volume342-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.alternativeName이주미-
dc.contributor.alternativeName김태형-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName박경선-
dc.contributor.alternativeName장세복-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName김희수-
dc.identifier.bibliographicCitationGene, vol. 342, no. 2, pp. 283-292-
dc.identifier.doi10.1016/j.gene.2004.08.007-
dc.subject.keywordCancer cells-
dc.subject.keywordExpression-
dc.subject.keywordHERV-S-
dc.subject.keywordHuman tissues-
dc.subject.keywordPhylogeny-
dc.subject.keywordPrimates-
dc.subject.localcancer cell-
dc.subject.localCancer cells-
dc.subject.localCancer cell-
dc.subject.localexpression-
dc.subject.localExpression-
dc.subject.localHERV-S-
dc.subject.localhuman tissue-
dc.subject.localHuman tissues-
dc.subject.localHuman tissue-
dc.subject.localphylogeny-
dc.subject.localPhylogeny-
dc.subject.localprimate-
dc.subject.localPrimates-
dc.subject.localPrimate-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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