Inhibitory effects of bufadienolides on interleukin-6 in MH-60 cells

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dc.contributor.authorA Enomoto-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorK Komiyama-
dc.contributor.authorM Hayashi-
dc.date.accessioned2017-04-19T09:02:11Z-
dc.date.available2017-04-19T09:02:11Z-
dc.date.issued2004-
dc.identifier.issn01633864-
dc.identifier.uri10.1021/np049950eko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6794-
dc.description.abstractDerivatives of bufogenin isolated from the skin of the Chinese toad, Bufo bufo gargarizans Cantor ("Ch'an Su"), and several semisynthetic derivatives of 20β,21β-epoxy-resibufogenin (13) have been evaluated for interleukin-6 (IL-6) antagonistic activity due to their growth-inhibitory activities on IL-6-dependent MH-60 cells. Among the naturally derived compounds (1-17), 20S,21-epoxy-resibufogenin formate (1) showed potent inhibitory activity on the IL-6-dependent growth of MH-60 cells. Epoxide groups at both the C-14, C-15 and C-20, C-21 positions are required to exhibit this type of activity. Compounds acetylated at the C-16 position (7 and 9-11) showed a loss of activity. An oxo group at the C-3 position (8, 14, and 15) resulted in cytotoxicity for both cell lines. Stereochemistry is important for selectivity on suppression of IL-6 activity. Among the semisynthetic derivatives (18-25) of 13, compound 19, with an acetyl group introduced at the C-3 position in comparison to 13, demonstrated considerable growth inhibition of IL-6-dependent MH-60 cells.-
dc.publisherAmer Chem Soc-
dc.titleInhibitory effects of bufadienolides on interleukin-6 in MH-60 cells-
dc.title.alternativeInhibitory effects of bufadienolides on interleukin-6 in MH-60 cells-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number12-
dc.citation.endPage2072-
dc.citation.startPage2070-
dc.citation.volume67-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeNameEnomoto-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeNameKomiyama-
dc.contributor.alternativeNameHayashi-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 67, no. 12, pp. 2070-2072-
dc.identifier.doi10.1021/np049950e-
dc.subject.keywordinterleukin 6-
dc.subject.keywordanimal cell-
dc.subject.keywordcell growth-
dc.subject.keyworddrug effect-
dc.subject.keywordinterleukin-6-
dc.subject.keywordtumor cells, cultured-
dc.subject.localinterleukin 6-
dc.subject.localinterleukin 6 (IL-6)-
dc.subject.localanimal cell-
dc.subject.localcell growth-
dc.subject.localCell growth-
dc.subject.localdrug effect-
dc.subject.localinterleukin-6-
dc.subject.localInterleukin-6-
dc.subject.localtumor cells, cultured-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
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